| http://purl.uniprot.org/citations/23109837 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23109837 | http://www.w3.org/2000/01/rdf-schema#comment | "In this study we aimed to confirm the emerging role of Chromatin Assembly Factor 1 (CAF-1 p60) as a new proliferation and prognostic marker for cancer and to test the usefulness of the tissue microarray technique (TMA) for CAF-1 p60 rapid screening in several human malignancies. CAF-1 is a histone chaperone, regulating chromatin dynamics during DNA replication and repair in eukaryotics. TMA is a powerful high-throughput methodology in the study of cancer, allowing simultaneous assessment of different biomarkers within large numbers of tissue specimens. We generated TMA taking 3 mm diameter-core biopsies from oral squamous cell carcinoma, prostate cancer, salivary gland tumours and skin melanoma specimens, which had been previously tested for CAF-1 p60 on routine tissue sections. We also analysed, for the first time, 30 larynx and 30 skin squamous cell carcinomas. CAF-1 p60 resulted over-expressed in both the tissue sections and the TMA specimens, with the highest levels of expression in tumours which were more aggressive and metastasizing. Notably, a high degree of agreement was found between the CAF-1 p60 assessment on TMAs and on routine tissue sections. Our findings confirm the prognostic role of CAF-1 p60 and indicate TMA as a really advantageous method for CAF-1 p60 immunohistochemical screening, allowing savings on both tissue quantity and operator-time."xsd:string |
| http://purl.uniprot.org/citations/23109837 | http://purl.org/dc/terms/identifier | "doi:10.3390/ijms130911044"xsd:string |
| http://purl.uniprot.org/citations/23109837 | http://purl.uniprot.org/core/author | "De Rosa G."xsd:string |
| http://purl.uniprot.org/citations/23109837 | http://purl.uniprot.org/core/author | "Russo D."xsd:string |
| http://purl.uniprot.org/citations/23109837 | http://purl.uniprot.org/core/author | "Mascolo M."xsd:string |
| http://purl.uniprot.org/citations/23109837 | http://purl.uniprot.org/core/author | "Merolla F."xsd:string |
| http://purl.uniprot.org/citations/23109837 | http://purl.uniprot.org/core/author | "Staibano S."xsd:string |
| http://purl.uniprot.org/citations/23109837 | http://purl.uniprot.org/core/author | "Ilardi G."xsd:string |
| http://purl.uniprot.org/citations/23109837 | http://purl.uniprot.org/core/author | "Vecchione M.L."xsd:string |
| http://purl.uniprot.org/citations/23109837 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23109837 | http://purl.uniprot.org/core/name | "Int J Mol Sci"xsd:string |
| http://purl.uniprot.org/citations/23109837 | http://purl.uniprot.org/core/pages | "11044-11062"xsd:string |
| http://purl.uniprot.org/citations/23109837 | http://purl.uniprot.org/core/title | "Tissue microarray-based evaluation of Chromatin Assembly Factor-1 (CAF-1)/p60 as tumour prognostic marker."xsd:string |
| http://purl.uniprot.org/citations/23109837 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/23109837 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23109837 |
| http://purl.uniprot.org/citations/23109837 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23109837 |
| http://purl.uniprot.org/uniprot/#_B2R7X3-mappedCitation-23109837 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23109837 |
| http://purl.uniprot.org/uniprot/#_Q13112-mappedCitation-23109837 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23109837 |
| http://purl.uniprot.org/uniprot/Q13112 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23109837 |
| http://purl.uniprot.org/uniprot/B2R7X3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23109837 |