| http://purl.uniprot.org/citations/23166356 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23166356 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23166356 | http://www.w3.org/2000/01/rdf-schema#comment | "The BCL6 proto-oncogene encodes a transcriptional repressor that is required for germinal center (GC) formation and whose de-regulation is involved in lymphomagenesis. Although substantial evidence indicates that BCL6 exerts its function by repressing the transcription of hundreds of protein-coding genes, its potential role in regulating gene expression via microRNAs (miRNAs) is not known. We have identified a core of 15 miRNAs that show binding of BCL6 in their genomic loci and are down-regulated in GC B cells. Among BCL6 validated targets, miR-155 and miR-361 directly modulate AID expression, indicating that via repression of these miRNAs, BCL6 up-regulates AID. Similarly, the expression of additional genes relevant for the GC phenotype, including SPI1, IRF8, and MYB, appears to be sustained via BCL6-mediated repression of miR-155. These findings identify a novel mechanism by which BCL6, in addition to repressing protein coding genes, promotes the expression of important GC functions by repressing specific miRNAs."xsd:string |
| http://purl.uniprot.org/citations/23166356 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20121387"xsd:string |
| http://purl.uniprot.org/citations/23166356 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20121387"xsd:string |
| http://purl.uniprot.org/citations/23166356 | http://purl.uniprot.org/core/author | "Holmes A.B."xsd:string |
| http://purl.uniprot.org/citations/23166356 | http://purl.uniprot.org/core/author | "Holmes A.B."xsd:string |
| http://purl.uniprot.org/citations/23166356 | http://purl.uniprot.org/core/author | "Schneider C."xsd:string |
| http://purl.uniprot.org/citations/23166356 | http://purl.uniprot.org/core/author | "Schneider C."xsd:string |
| http://purl.uniprot.org/citations/23166356 | http://purl.uniprot.org/core/author | "Shen Q."xsd:string |
| http://purl.uniprot.org/citations/23166356 | http://purl.uniprot.org/core/author | "Shen Q."xsd:string |
| http://purl.uniprot.org/citations/23166356 | http://purl.uniprot.org/core/author | "Basso K."xsd:string |
| http://purl.uniprot.org/citations/23166356 | http://purl.uniprot.org/core/author | "Basso K."xsd:string |
| http://purl.uniprot.org/citations/23166356 | http://purl.uniprot.org/core/author | "Dalla-Favera R."xsd:string |
| http://purl.uniprot.org/citations/23166356 | http://purl.uniprot.org/core/author | "Dalla-Favera R."xsd:string |
| http://purl.uniprot.org/citations/23166356 | http://purl.uniprot.org/core/author | "Leslie C."xsd:string |
| http://purl.uniprot.org/citations/23166356 | http://purl.uniprot.org/core/author | "Leslie C."xsd:string |
| http://purl.uniprot.org/citations/23166356 | http://purl.uniprot.org/core/author | "Setty M."xsd:string |
| http://purl.uniprot.org/citations/23166356 | http://purl.uniprot.org/core/author | "Setty M."xsd:string |
| http://purl.uniprot.org/citations/23166356 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23166356 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23166356 | http://purl.uniprot.org/core/name | "J. Exp. Med."xsd:string |
| http://purl.uniprot.org/citations/23166356 | http://purl.uniprot.org/core/name | "J. Exp. Med."xsd:string |
| http://purl.uniprot.org/citations/23166356 | http://purl.uniprot.org/core/pages | "2455-2465"xsd:string |
| http://purl.uniprot.org/citations/23166356 | http://purl.uniprot.org/core/pages | "2455-2465"xsd:string |