| http://purl.uniprot.org/citations/23177738 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23177738 | http://www.w3.org/2000/01/rdf-schema#comment | "Nuclear pore complexes (NPCs) and kinetochores perform distinct tasks, yet their shared ability to bind several proteins suggests their functions are intertwined. Among these shared proteins is Mad1p, a component of the yeast spindle assembly checkpoint (SAC). Here we describe a role for Mad1p in regulating nuclear import that employs its ability to sense a disruption of kinetochore-microtubule interactions during mitosis. We show that kinetochore-microtubule detachment arrests nuclear import mediated by the transport factor Kap121p through a mechanism that requires Mad1p cycling between unattached, metaphase kinetochores and binding sites at the NPC. This signaling pathway requires the Aurora B-like kinase Ipl1p, and the resulting transport changes inhibit the nuclear import of Glc7p, a phosphatase that acts as an Ipl1p antagonist. We propose that a distinct branch of the SAC exists in which Mad1p senses unattached kinetochores and, by altering NPC transport activity, regulates the nuclear environment of the spindle."xsd:string |
| http://purl.uniprot.org/citations/23177738 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2012.10.017"xsd:string |
| http://purl.uniprot.org/citations/23177738 | http://purl.uniprot.org/core/author | "Wozniak R.W."xsd:string |
| http://purl.uniprot.org/citations/23177738 | http://purl.uniprot.org/core/author | "Ptak C."xsd:string |
| http://purl.uniprot.org/citations/23177738 | http://purl.uniprot.org/core/author | "Cairo L.V."xsd:string |
| http://purl.uniprot.org/citations/23177738 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23177738 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/23177738 | http://purl.uniprot.org/core/pages | "109-120"xsd:string |
| http://purl.uniprot.org/citations/23177738 | http://purl.uniprot.org/core/title | "Mitosis-specific regulation of nuclear transport by the spindle assembly checkpoint protein Mad1p."xsd:string |
| http://purl.uniprot.org/citations/23177738 | http://purl.uniprot.org/core/volume | "49"xsd:string |
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