| http://purl.uniprot.org/citations/23283301 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23283301 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23283301 | http://www.w3.org/2000/01/rdf-schema#comment | "Reduction of nutrient intake without malnutrition positively influences lifespan and healthspan from yeast to mice and exerts some beneficial effects also in humans. The AMPK-FoxO axis is one of the evolutionarily conserved nutrient-sensing pathways, and the FOXO3A locus is associated with human longevity. Interestingly, FoxO3A has been reported to be also a mitochondrial protein in mammalian cells and tissues. Here we report that glucose restriction triggers FoxO3A accumulation into mitochondria of fibroblasts and skeletal myotubes in an AMPK-dependent manner. A low-glucose regimen induces the formation of a protein complex containing FoxO3A, SIRT3, and mitochondrial RNA polymerase (mtRNAPol) at mitochondrial DNA-regulatory regions causing activation of the mitochondrial genome and a subsequent increase in mitochondrial respiration. Consistently, mitochondrial transcription increases in skeletal muscle of fasted mice, with a mitochondrial DNA-bound FoxO3A/SIRT3/mtRNAPol complex detectable also in vivo. Our results unveil a mitochondrial arm of the AMPK-FoxO3A axis acting as a recovery mechanism to sustain energy metabolism upon nutrient restriction."xsd:string |
| http://purl.uniprot.org/citations/23283301 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00018-012-1244-6"xsd:string |
| http://purl.uniprot.org/citations/23283301 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00018-012-1244-6"xsd:string |
| http://purl.uniprot.org/citations/23283301 | http://purl.uniprot.org/core/author | "Villani G."xsd:string |
| http://purl.uniprot.org/citations/23283301 | http://purl.uniprot.org/core/author | "Villani G."xsd:string |
| http://purl.uniprot.org/citations/23283301 | http://purl.uniprot.org/core/author | "Chiacchiera F."xsd:string |
| http://purl.uniprot.org/citations/23283301 | http://purl.uniprot.org/core/author | "Chiacchiera F."xsd:string |
| http://purl.uniprot.org/citations/23283301 | http://purl.uniprot.org/core/author | "Finley L.W."xsd:string |
| http://purl.uniprot.org/citations/23283301 | http://purl.uniprot.org/core/author | "Finley L.W."xsd:string |
| http://purl.uniprot.org/citations/23283301 | http://purl.uniprot.org/core/author | "Fusella A."xsd:string |
| http://purl.uniprot.org/citations/23283301 | http://purl.uniprot.org/core/author | "Fusella A."xsd:string |
| http://purl.uniprot.org/citations/23283301 | http://purl.uniprot.org/core/author | "Grossi V."xsd:string |
| http://purl.uniprot.org/citations/23283301 | http://purl.uniprot.org/core/author | "Grossi V."xsd:string |
| http://purl.uniprot.org/citations/23283301 | http://purl.uniprot.org/core/author | "Haigis M.C."xsd:string |
| http://purl.uniprot.org/citations/23283301 | http://purl.uniprot.org/core/author | "Haigis M.C."xsd:string |
| http://purl.uniprot.org/citations/23283301 | http://purl.uniprot.org/core/author | "Latorre D."xsd:string |
| http://purl.uniprot.org/citations/23283301 | http://purl.uniprot.org/core/author | "Latorre D."xsd:string |
| http://purl.uniprot.org/citations/23283301 | http://purl.uniprot.org/core/author | "Matrone A."xsd:string |
| http://purl.uniprot.org/citations/23283301 | http://purl.uniprot.org/core/author | "Matrone A."xsd:string |
| http://purl.uniprot.org/citations/23283301 | http://purl.uniprot.org/core/author | "Peserico A."xsd:string |
| http://purl.uniprot.org/citations/23283301 | http://purl.uniprot.org/core/author | "Peserico A."xsd:string |
| http://purl.uniprot.org/citations/23283301 | http://purl.uniprot.org/core/author | "Puri P.L."xsd:string |
| http://purl.uniprot.org/citations/23283301 | http://purl.uniprot.org/core/author | "Puri P.L."xsd:string |