| http://purl.uniprot.org/citations/23306439 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23306439 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23306439 | http://www.w3.org/2000/01/rdf-schema#comment | "DNA double-strand breaks (DSBs) represent a threat to the genome because they can lead to the loss of genetic information and chromosome rearrangements. The DNA repair protein p53 binding protein 1 (53BP1) protects the genome by limiting nucleolytic processing of DSBs by a mechanism that requires its phosphorylation, but whether 53BP1 does so directly is not known. Here, we identify Rap1-interacting factor 1 (Rif1) as an ATM (ataxia-telangiectasia mutated) phosphorylation-dependent interactor of 53BP1 and show that absence of Rif1 results in 5'-3' DNA-end resection in mice. Consistent with enhanced DNA resection, Rif1 deficiency impairs DNA repair in the G(1) and S phases of the cell cycle, interferes with class switch recombination in B lymphocytes, and leads to accumulation of chromosome DSBs."xsd:string |
| http://purl.uniprot.org/citations/23306439 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1230624"xsd:string |
| http://purl.uniprot.org/citations/23306439 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1230624"xsd:string |
| http://purl.uniprot.org/citations/23306439 | http://purl.uniprot.org/core/author | "Chait B.T."xsd:string |
| http://purl.uniprot.org/citations/23306439 | http://purl.uniprot.org/core/author | "Chait B.T."xsd:string |
| http://purl.uniprot.org/citations/23306439 | http://purl.uniprot.org/core/author | "Zhang W."xsd:string |
| http://purl.uniprot.org/citations/23306439 | http://purl.uniprot.org/core/author | "Zhang W."xsd:string |
| http://purl.uniprot.org/citations/23306439 | http://purl.uniprot.org/core/author | "Resch W."xsd:string |
| http://purl.uniprot.org/citations/23306439 | http://purl.uniprot.org/core/author | "Resch W."xsd:string |
| http://purl.uniprot.org/citations/23306439 | http://purl.uniprot.org/core/author | "Yamane A."xsd:string |
| http://purl.uniprot.org/citations/23306439 | http://purl.uniprot.org/core/author | "Yamane A."xsd:string |
| http://purl.uniprot.org/citations/23306439 | http://purl.uniprot.org/core/author | "Nussenzweig A."xsd:string |
| http://purl.uniprot.org/citations/23306439 | http://purl.uniprot.org/core/author | "Nussenzweig A."xsd:string |
| http://purl.uniprot.org/citations/23306439 | http://purl.uniprot.org/core/author | "Feldhahn N."xsd:string |
| http://purl.uniprot.org/citations/23306439 | http://purl.uniprot.org/core/author | "Feldhahn N."xsd:string |
| http://purl.uniprot.org/citations/23306439 | http://purl.uniprot.org/core/author | "Casellas R."xsd:string |
| http://purl.uniprot.org/citations/23306439 | http://purl.uniprot.org/core/author | "Casellas R."xsd:string |
| http://purl.uniprot.org/citations/23306439 | http://purl.uniprot.org/core/author | "Gitlin A.D."xsd:string |
| http://purl.uniprot.org/citations/23306439 | http://purl.uniprot.org/core/author | "Gitlin A.D."xsd:string |
| http://purl.uniprot.org/citations/23306439 | http://purl.uniprot.org/core/author | "Nussenzweig M.C."xsd:string |
| http://purl.uniprot.org/citations/23306439 | http://purl.uniprot.org/core/author | "Nussenzweig M.C."xsd:string |
| http://purl.uniprot.org/citations/23306439 | http://purl.uniprot.org/core/author | "Jankovic M."xsd:string |
| http://purl.uniprot.org/citations/23306439 | http://purl.uniprot.org/core/author | "Jankovic M."xsd:string |