| http://purl.uniprot.org/citations/23374346 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23374346 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23374346 | http://www.w3.org/2000/01/rdf-schema#comment | "Protection against oxidative damage caused by excessive reactive oxygen species (ROS) by an antioxidant network is essential for the health of tissues, especially in the cardiovascular system. Here, we identified a gene with important antioxidant features by analyzing a null allele of zebrafish ubiad1, called barolo (bar). bar mutants show specific cardiovascular failure due to oxidative stress and ROS-mediated cellular damage. Human UBIAD1 is a nonmitochondrial prenyltransferase that synthesizes CoQ10 in the Golgi membrane compartment. Loss of UBIAD1 reduces the cytosolic pool of the antioxidant CoQ10 and leads to ROS-mediated lipid peroxidation in vascular cells. Surprisingly, inhibition of eNOS prevents Ubiad1-dependent cardiovascular oxidative damage, suggesting a crucial role for this enzyme and nonmitochondrial CoQ10 in NO signaling. These findings identify UBIAD1 as a nonmitochondrial CoQ10-forming enzyme with specific cardiovascular protective function via the modulation of eNOS activity."xsd:string |
| http://purl.uniprot.org/citations/23374346 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2013.01.013"xsd:string |
| http://purl.uniprot.org/citations/23374346 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2013.01.013"xsd:string |
| http://purl.uniprot.org/citations/23374346 | http://purl.uniprot.org/core/author | "Santoro M.M."xsd:string |
| http://purl.uniprot.org/citations/23374346 | http://purl.uniprot.org/core/author | "Santoro M.M."xsd:string |
| http://purl.uniprot.org/citations/23374346 | http://purl.uniprot.org/core/author | "Bakkers J."xsd:string |
| http://purl.uniprot.org/citations/23374346 | http://purl.uniprot.org/core/author | "Bakkers J."xsd:string |
| http://purl.uniprot.org/citations/23374346 | http://purl.uniprot.org/core/author | "Stainier D.Y."xsd:string |
| http://purl.uniprot.org/citations/23374346 | http://purl.uniprot.org/core/author | "Stainier D.Y."xsd:string |
| http://purl.uniprot.org/citations/23374346 | http://purl.uniprot.org/core/author | "Murphy M.P."xsd:string |
| http://purl.uniprot.org/citations/23374346 | http://purl.uniprot.org/core/author | "Murphy M.P."xsd:string |
| http://purl.uniprot.org/citations/23374346 | http://purl.uniprot.org/core/author | "Silengo L."xsd:string |
| http://purl.uniprot.org/citations/23374346 | http://purl.uniprot.org/core/author | "Silengo L."xsd:string |
| http://purl.uniprot.org/citations/23374346 | http://purl.uniprot.org/core/author | "Turco E."xsd:string |
| http://purl.uniprot.org/citations/23374346 | http://purl.uniprot.org/core/author | "Turco E."xsd:string |
| http://purl.uniprot.org/citations/23374346 | http://purl.uniprot.org/core/author | "Digilio G."xsd:string |
| http://purl.uniprot.org/citations/23374346 | http://purl.uniprot.org/core/author | "Digilio G."xsd:string |
| http://purl.uniprot.org/citations/23374346 | http://purl.uniprot.org/core/author | "De Luca E."xsd:string |
| http://purl.uniprot.org/citations/23374346 | http://purl.uniprot.org/core/author | "De Luca E."xsd:string |
| http://purl.uniprot.org/citations/23374346 | http://purl.uniprot.org/core/author | "Postel R."xsd:string |
| http://purl.uniprot.org/citations/23374346 | http://purl.uniprot.org/core/author | "Postel R."xsd:string |
| http://purl.uniprot.org/citations/23374346 | http://purl.uniprot.org/core/author | "Catanzaro V."xsd:string |
| http://purl.uniprot.org/citations/23374346 | http://purl.uniprot.org/core/author | "Catanzaro V."xsd:string |