| http://purl.uniprot.org/citations/23381138 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23381138 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23381138 | http://www.w3.org/2000/01/rdf-schema#comment | "Tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6) is a key regulator of the activation of transcription factor NF-κB by the interleukin-1 receptor (IL-1R)/Toll-like receptor (TLR) superfamily. Recruitment of TRAF6 to the receptor-associated IRAK1-IRAK4-MyD88 adaptor protein complex induces lysine 63 (K63) autopolyubiquitination of TRAF6, which leads to further recruitment of downstream regulators, such as TAB2/3 and TAK1, and subsequently triggers NF-κB activation. Here, we identified the putative E2 ubiquitin-conjugating (UBC) enzyme UBE2O as a novel negative regulator of TRAF6-dependent NF-κB signaling. We found that UBE2O binds to TRAF6 to inhibit its K63-polyubiquitination, and to prevent the activation of NF-κB by IL-1β and lipopolysaccharides (LPS). We further show that the inhibitory effect of UBE2O is independent of its carboxy-terminal UBC domain. In contrast, we found that UBE2O acts to disrupt the IL-1β-induced association of TRAF6 with MyD88. These results provide novel insight into the regulation of signaling by IL-1R/TLR and TRAF6."xsd:string |
| http://purl.uniprot.org/citations/23381138 | http://purl.org/dc/terms/identifier | "doi:10.1038/cr.2013.21"xsd:string |
| http://purl.uniprot.org/citations/23381138 | http://purl.org/dc/terms/identifier | "doi:10.1038/cr.2013.21"xsd:string |
| http://purl.uniprot.org/citations/23381138 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/23381138 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/23381138 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/23381138 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/23381138 | http://purl.uniprot.org/core/author | "Zhang L."xsd:string |
| http://purl.uniprot.org/citations/23381138 | http://purl.uniprot.org/core/author | "Zhang L."xsd:string |
| http://purl.uniprot.org/citations/23381138 | http://purl.uniprot.org/core/author | "ten Dijke P."xsd:string |
| http://purl.uniprot.org/citations/23381138 | http://purl.uniprot.org/core/author | "ten Dijke P."xsd:string |
| http://purl.uniprot.org/citations/23381138 | http://purl.uniprot.org/core/author | "van Dam H."xsd:string |
| http://purl.uniprot.org/citations/23381138 | http://purl.uniprot.org/core/author | "van Dam H."xsd:string |
| http://purl.uniprot.org/citations/23381138 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23381138 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23381138 | http://purl.uniprot.org/core/name | "Cell Res."xsd:string |
| http://purl.uniprot.org/citations/23381138 | http://purl.uniprot.org/core/name | "Cell Res."xsd:string |
| http://purl.uniprot.org/citations/23381138 | http://purl.uniprot.org/core/pages | "366-377"xsd:string |
| http://purl.uniprot.org/citations/23381138 | http://purl.uniprot.org/core/pages | "366-377"xsd:string |
| http://purl.uniprot.org/citations/23381138 | http://purl.uniprot.org/core/title | "UBE2O negatively regulates TRAF6-mediated NF-kappaB activation by inhibiting TRAF6 polyubiquitination."xsd:string |
| http://purl.uniprot.org/citations/23381138 | http://purl.uniprot.org/core/title | "UBE2O negatively regulates TRAF6-mediated NF-kappaB activation by inhibiting TRAF6 polyubiquitination."xsd:string |
| http://purl.uniprot.org/citations/23381138 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/23381138 | http://purl.uniprot.org/core/volume | "23"xsd:string |