| http://purl.uniprot.org/citations/23382219 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23382219 | http://www.w3.org/2000/01/rdf-schema#comment | "Transit of proteins through the endosomal organelle following endocytosis is critical for regulating the homeostasis of cell-surface proteins and controlling signal transduction pathways. However, the mechanisms that control these membrane-transport processes are poorly understood. The Phox-homology (PX) domain-containing proteins sorting nexin (SNX) 17, SNX27, and SNX31 have emerged recently as key regulators of endosomal recycling and bind conserved Asn-Pro-Xaa-Tyr-sorting signals in transmembrane cargos via an atypical band, 4.1/ezrin/radixin/moesin (FERM) domain. Here we present the crystal structure of the SNX17 FERM domain bound to the sorting motif of the P-selectin adhesion protein, revealing both the architecture of the atypical FERM domain and the molecular basis for recognition of these essential sorting sequences. We further show that the PX-FERM proteins share a promiscuous ability to bind a wide array of putative cargo molecules, including receptor tyrosine kinases, and propose a model for their coordinated molecular interactions with membrane, cargo, and regulatory proteins."xsd:string |
| http://purl.uniprot.org/citations/23382219 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1216229110"xsd:string |
| http://purl.uniprot.org/citations/23382219 | http://purl.uniprot.org/core/author | "Ghai R."xsd:string |
| http://purl.uniprot.org/citations/23382219 | http://purl.uniprot.org/core/author | "Liu H."xsd:string |
| http://purl.uniprot.org/citations/23382219 | http://purl.uniprot.org/core/author | "Teasdale R.D."xsd:string |
| http://purl.uniprot.org/citations/23382219 | http://purl.uniprot.org/core/author | "Collins B.M."xsd:string |
| http://purl.uniprot.org/citations/23382219 | http://purl.uniprot.org/core/author | "Li S.S."xsd:string |
| http://purl.uniprot.org/citations/23382219 | http://purl.uniprot.org/core/author | "Bugarcic A."xsd:string |
| http://purl.uniprot.org/citations/23382219 | http://purl.uniprot.org/core/author | "Skeldal S."xsd:string |
| http://purl.uniprot.org/citations/23382219 | http://purl.uniprot.org/core/author | "Norwood S.J."xsd:string |
| http://purl.uniprot.org/citations/23382219 | http://purl.uniprot.org/core/author | "Coulson E.J."xsd:string |
| http://purl.uniprot.org/citations/23382219 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23382219 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/23382219 | http://purl.uniprot.org/core/pages | "E643-52"xsd:string |
| http://purl.uniprot.org/citations/23382219 | http://purl.uniprot.org/core/title | "Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins."xsd:string |
| http://purl.uniprot.org/citations/23382219 | http://purl.uniprot.org/core/volume | "110"xsd:string |
| http://purl.uniprot.org/citations/23382219 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23382219 |
| http://purl.uniprot.org/citations/23382219 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23382219 |
| http://purl.uniprot.org/uniprot/P16066#attribution-6382EC52F66F3037AB93E6E041E6140F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23382219 |
| http://purl.uniprot.org/uniprot/P18293#attribution-EB1255A01ABBCD2D2A67798D42DE4854 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23382219 |
| http://purl.uniprot.org/uniprot/P12023#attribution-EB1255A01ABBCD2D2A67798D42DE4854 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23382219 |
| http://purl.uniprot.org/uniprot/P05067#attribution-6382EC52F66F3037AB93E6E041E6140F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23382219 |
| http://purl.uniprot.org/uniprot/Q8WXG9#attribution-6382EC52F66F3037AB93E6E041E6140F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23382219 |
| http://purl.uniprot.org/uniprot/Q8VHN7#attribution-EB1255A01ABBCD2D2A67798D42DE4854 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23382219 |