| http://purl.uniprot.org/citations/23395171 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23395171 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23395171 | http://www.w3.org/2000/01/rdf-schema#comment | "Osteoclast maturation and function primarily depend on receptor activator of NF-κB ligand (RANKL)-mediated induction of nuclear factor of activated T cells c1 (NFATc1), which is further activated via increased intracellular calcium ([Ca(2+)](i)) oscillation. However, the coordination mechanism that mediates Ca(2+) oscillation during osteoclastogenesis remains ill defined. Here, we identified transmembrane protein 64 (Tmem64) as a regulator of Ca(2+) oscillation during osteoclastogenesis. We found that Tmem64-deficient mice exhibit increased bone mass due in part to impaired osteoclast formation. Using in vitro osteoclast culture systems, we show here that Tmem64 interacts with sarcoplasmic endoplasmic reticulum Ca(2+) ATPase 2 (SERCA2) and modulates its activity. Consequently, Tmem64 deficiency significantly diminishes RANKL-induced [Ca(2+)](i) oscillation, which results in reduced Ca(2+)/calmodulin-dependent protein kinases (CaMK) IV and mitochondrial ROS, both of which contribute to achieving the CREB activity necessary for osteoclast formation. These data demonstrate that Tmem64 is a positive modulator of osteoclast differentiation via SERCA2-dependent Ca(2+) signaling."xsd:string |
| http://purl.uniprot.org/citations/23395171 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cmet.2013.01.002"xsd:string |
| http://purl.uniprot.org/citations/23395171 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cmet.2013.01.002"xsd:string |
| http://purl.uniprot.org/citations/23395171 | http://purl.uniprot.org/core/author | "Han D."xsd:string |
| http://purl.uniprot.org/citations/23395171 | http://purl.uniprot.org/core/author | "Han D."xsd:string |
| http://purl.uniprot.org/citations/23395171 | http://purl.uniprot.org/core/author | "Lee J.H."xsd:string |
| http://purl.uniprot.org/citations/23395171 | http://purl.uniprot.org/core/author | "Lee J.H."xsd:string |
| http://purl.uniprot.org/citations/23395171 | http://purl.uniprot.org/core/author | "Kim H."xsd:string |
| http://purl.uniprot.org/citations/23395171 | http://purl.uniprot.org/core/author | "Kim H."xsd:string |
| http://purl.uniprot.org/citations/23395171 | http://purl.uniprot.org/core/author | "Lee S.H."xsd:string |
| http://purl.uniprot.org/citations/23395171 | http://purl.uniprot.org/core/author | "Lee S.H."xsd:string |
| http://purl.uniprot.org/citations/23395171 | http://purl.uniprot.org/core/author | "Choi Y."xsd:string |
| http://purl.uniprot.org/citations/23395171 | http://purl.uniprot.org/core/author | "Choi Y."xsd:string |
| http://purl.uniprot.org/citations/23395171 | http://purl.uniprot.org/core/author | "Jeong B.C."xsd:string |
| http://purl.uniprot.org/citations/23395171 | http://purl.uniprot.org/core/author | "Jeong B.C."xsd:string |
| http://purl.uniprot.org/citations/23395171 | http://purl.uniprot.org/core/author | "Kim T."xsd:string |
| http://purl.uniprot.org/citations/23395171 | http://purl.uniprot.org/core/author | "Kim T."xsd:string |
| http://purl.uniprot.org/citations/23395171 | http://purl.uniprot.org/core/author | "Cho I.T."xsd:string |
| http://purl.uniprot.org/citations/23395171 | http://purl.uniprot.org/core/author | "Cho I.T."xsd:string |
| http://purl.uniprot.org/citations/23395171 | http://purl.uniprot.org/core/author | "Negishi-Koga T."xsd:string |
| http://purl.uniprot.org/citations/23395171 | http://purl.uniprot.org/core/author | "Negishi-Koga T."xsd:string |
| http://purl.uniprot.org/citations/23395171 | http://purl.uniprot.org/core/author | "Prasad V."xsd:string |
| http://purl.uniprot.org/citations/23395171 | http://purl.uniprot.org/core/author | "Prasad V."xsd:string |