| http://purl.uniprot.org/citations/23399697 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23399697 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23399697 | http://www.w3.org/2000/01/rdf-schema#comment | "The innate immune response to virus must be balanced to eliminate infection yet limit damaging inflammation. A critical arm of the antiviral response is launched by the retinoic acid-inducible-gene I (RIG-I) protein. RIG-I is activated by viral RNA then associates with the mitochondrial antiviral signaling (MAVS) protein to subsequently induce potent inflammatory cytokines. Here, we demonstrate the mitochondrial E3 ubiquitin protein ligase 1 (MUL1) is a crucial moderator of RIG-I signaling. MUL1 is localized to the mitochondria where it interacts with MAVS and catalyzes RIG-I post-translational modifications that inhibit RIG-I-dependent cell signaling. Accordingly, depletion of MUL1 potentiated RIG-I mediated nuclear factor-kappa B (NF-κB) and interferon (IFN) β reporter activity. Moreover, depletion of MUL1 boosted the antiviral response and increased proinflammatory cytokines following challenge with the RNA mimetic poly I:C and Sendai virus. We therefore submit that MUL1 is a novel regulator of the RIG-I-like receptor-dependent antiviral response, that otherwise functions to limit inflammation."xsd:string |
| http://purl.uniprot.org/citations/23399697 | http://purl.org/dc/terms/identifier | "doi:10.1038/icb.2013.7"xsd:string |
| http://purl.uniprot.org/citations/23399697 | http://purl.org/dc/terms/identifier | "doi:10.1038/icb.2013.7"xsd:string |
| http://purl.uniprot.org/citations/23399697 | http://purl.uniprot.org/core/author | "Wang D."xsd:string |
| http://purl.uniprot.org/citations/23399697 | http://purl.uniprot.org/core/author | "Wang D."xsd:string |
| http://purl.uniprot.org/citations/23399697 | http://purl.uniprot.org/core/author | "Borg N.A."xsd:string |
| http://purl.uniprot.org/citations/23399697 | http://purl.uniprot.org/core/author | "Borg N.A."xsd:string |
| http://purl.uniprot.org/citations/23399697 | http://purl.uniprot.org/core/author | "Nagley P."xsd:string |
| http://purl.uniprot.org/citations/23399697 | http://purl.uniprot.org/core/author | "Nagley P."xsd:string |
| http://purl.uniprot.org/citations/23399697 | http://purl.uniprot.org/core/author | "Hertzog P.J."xsd:string |
| http://purl.uniprot.org/citations/23399697 | http://purl.uniprot.org/core/author | "Hertzog P.J."xsd:string |
| http://purl.uniprot.org/citations/23399697 | http://purl.uniprot.org/core/author | "Mansell A."xsd:string |
| http://purl.uniprot.org/citations/23399697 | http://purl.uniprot.org/core/author | "Mansell A."xsd:string |
| http://purl.uniprot.org/citations/23399697 | http://purl.uniprot.org/core/author | "Sadler A."xsd:string |
| http://purl.uniprot.org/citations/23399697 | http://purl.uniprot.org/core/author | "Sadler A."xsd:string |
| http://purl.uniprot.org/citations/23399697 | http://purl.uniprot.org/core/author | "Jenkins K."xsd:string |
| http://purl.uniprot.org/citations/23399697 | http://purl.uniprot.org/core/author | "Jenkins K."xsd:string |
| http://purl.uniprot.org/citations/23399697 | http://purl.uniprot.org/core/author | "Hjerrild K."xsd:string |
| http://purl.uniprot.org/citations/23399697 | http://purl.uniprot.org/core/author | "Hjerrild K."xsd:string |
| http://purl.uniprot.org/citations/23399697 | http://purl.uniprot.org/core/author | "Gould J."xsd:string |
| http://purl.uniprot.org/citations/23399697 | http://purl.uniprot.org/core/author | "Gould J."xsd:string |
| http://purl.uniprot.org/citations/23399697 | http://purl.uniprot.org/core/author | "Khoo J.J."xsd:string |
| http://purl.uniprot.org/citations/23399697 | http://purl.uniprot.org/core/author | "Khoo J.J."xsd:string |