| http://purl.uniprot.org/citations/23543754 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23543754 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23543754 | http://www.w3.org/2000/01/rdf-schema#comment | "Regulatory T cells (Tregs) play a pivotal role in the maintenance of immunological self-tolerance. Deficiency or dysfunction of Tregs leads to severe autoimmune diseases. Although the forkhead/winged-helix family member FOXP3 is critical for Treg differentiation and function, the molecular basis for FOXP3 function remains unclear. In this study, we identified and characterized a human-specific FOXP3-interacting protein, referred to as FIK (FOXP3-interacting KRAB domain-containing protein). FIK is highly expressed in Tregs and acts as a bridging molecule to link FOXP3 with the chromatin-remodeling scaffold protein KAP1 (TIF-1β/TRIM28). Disruption of the FOXP3-FIK-KAP1 complex in Tregs restored expression of FOXP3-target genes and abrogated the suppressor activity of the Tregs. These data demonstrate a critical role for FIK in regulating FOXP3 activity and Treg function."xsd:string |
| http://purl.uniprot.org/citations/23543754 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1203561"xsd:string |
| http://purl.uniprot.org/citations/23543754 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1203561"xsd:string |
| http://purl.uniprot.org/citations/23543754 | http://purl.uniprot.org/core/author | "Du J."xsd:string |
| http://purl.uniprot.org/citations/23543754 | http://purl.uniprot.org/core/author | "Du J."xsd:string |
| http://purl.uniprot.org/citations/23543754 | http://purl.uniprot.org/core/author | "Martin S."xsd:string |
| http://purl.uniprot.org/citations/23543754 | http://purl.uniprot.org/core/author | "Martin S."xsd:string |
| http://purl.uniprot.org/citations/23543754 | http://purl.uniprot.org/core/author | "Huang C."xsd:string |
| http://purl.uniprot.org/citations/23543754 | http://purl.uniprot.org/core/author | "Huang C."xsd:string |
| http://purl.uniprot.org/citations/23543754 | http://purl.uniprot.org/core/author | "Riley J.L."xsd:string |
| http://purl.uniprot.org/citations/23543754 | http://purl.uniprot.org/core/author | "Riley J.L."xsd:string |
| http://purl.uniprot.org/citations/23543754 | http://purl.uniprot.org/core/author | "Ziegler S.F."xsd:string |
| http://purl.uniprot.org/citations/23543754 | http://purl.uniprot.org/core/author | "Ziegler S.F."xsd:string |
| http://purl.uniprot.org/citations/23543754 | http://purl.uniprot.org/core/author | "Bluestone J.A."xsd:string |
| http://purl.uniprot.org/citations/23543754 | http://purl.uniprot.org/core/author | "Bluestone J.A."xsd:string |
| http://purl.uniprot.org/citations/23543754 | http://purl.uniprot.org/core/author | "Buckner J.H."xsd:string |
| http://purl.uniprot.org/citations/23543754 | http://purl.uniprot.org/core/author | "Buckner J.H."xsd:string |
| http://purl.uniprot.org/citations/23543754 | http://purl.uniprot.org/core/author | "Pfleger C."xsd:string |
| http://purl.uniprot.org/citations/23543754 | http://purl.uniprot.org/core/author | "Pfleger C."xsd:string |
| http://purl.uniprot.org/citations/23543754 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23543754 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23543754 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/23543754 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |