| http://purl.uniprot.org/citations/2360047 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2360047 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2360047 | http://www.w3.org/2000/01/rdf-schema#comment | "The vast repertoire of immunoglobulins and T cell receptors is generated, in part, by V(D)J recombination, a series of genomic rearrangements that occur specifically in developing lymphocytes. The recombination activating gene, RAG-1, which is a gene expressed exclusively in maturing lymphoid cells, was previously isolated. RAG-1 inefficiently induced V(D)J recombinase activity when transfected into fibroblasts, but cotransfection with an adjacent gene, RAG-2, has resulted in at least a 1000-fold increase in the frequency of recombination. The 2.1-kilobase RAG-2 complementary DNA encodes a putative protein of 527 amino acids whose sequence is unrelated to that of RAG-1. Like RAG-1, RAG-2 is conserved between species that carry out V(D)J recombination, and its expression pattern correlates precisely with that of V(D)J recombinase activity. In addition to being located just 8 kilobases apart, these convergently transcribed genes are unusual in that most, if not all, of their coding and 3' untranslated sequences are contained in single exons. RAG-1 and RAG-2 might activate the expression of the V(D)J recombinase but, more likely, they directly participate in the recombination reaction."xsd:string |
| http://purl.uniprot.org/citations/2360047 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.2360047"xsd:string |
| http://purl.uniprot.org/citations/2360047 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.2360047"xsd:string |
| http://purl.uniprot.org/citations/2360047 | http://purl.uniprot.org/core/author | "Baltimore D."xsd:string |
| http://purl.uniprot.org/citations/2360047 | http://purl.uniprot.org/core/author | "Baltimore D."xsd:string |
| http://purl.uniprot.org/citations/2360047 | http://purl.uniprot.org/core/author | "Schatz D.G."xsd:string |
| http://purl.uniprot.org/citations/2360047 | http://purl.uniprot.org/core/author | "Schatz D.G."xsd:string |
| http://purl.uniprot.org/citations/2360047 | http://purl.uniprot.org/core/author | "Oettinger M.A."xsd:string |
| http://purl.uniprot.org/citations/2360047 | http://purl.uniprot.org/core/author | "Oettinger M.A."xsd:string |
| http://purl.uniprot.org/citations/2360047 | http://purl.uniprot.org/core/author | "Gorka C."xsd:string |
| http://purl.uniprot.org/citations/2360047 | http://purl.uniprot.org/core/author | "Gorka C."xsd:string |
| http://purl.uniprot.org/citations/2360047 | http://purl.uniprot.org/core/date | "1990"xsd:gYear |
| http://purl.uniprot.org/citations/2360047 | http://purl.uniprot.org/core/date | "1990"xsd:gYear |
| http://purl.uniprot.org/citations/2360047 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/2360047 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/2360047 | http://purl.uniprot.org/core/pages | "1517-1523"xsd:string |
| http://purl.uniprot.org/citations/2360047 | http://purl.uniprot.org/core/pages | "1517-1523"xsd:string |
| http://purl.uniprot.org/citations/2360047 | http://purl.uniprot.org/core/title | "RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination."xsd:string |
| http://purl.uniprot.org/citations/2360047 | http://purl.uniprot.org/core/title | "RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination."xsd:string |
| http://purl.uniprot.org/citations/2360047 | http://purl.uniprot.org/core/volume | "248"xsd:string |
| http://purl.uniprot.org/citations/2360047 | http://purl.uniprot.org/core/volume | "248"xsd:string |
| http://purl.uniprot.org/citations/2360047 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/2360047 |
| http://purl.uniprot.org/citations/2360047 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/2360047 |