| http://purl.uniprot.org/citations/23644599 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23644599 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23644599 | http://www.w3.org/2000/01/rdf-schema#comment | "Tristetraprolin (TTP) is an RNA-binding protein that controls the inflammatory response by limiting the expression of several proinflammatory cytokines. TTP post-transcriptionally represses gene expression by interacting with AU-rich elements (AREs) in 3' untranslated regions of target mRNAs and subsequently engenders their deadenylation and decay. TTP accomplishes these tasks, at least in part, by recruiting the multisubunit CCR4-NOT deadenylase complex to the mRNA. Here we identify an evolutionarily conserved C-terminal motif in human TTP that directly binds a central domain of CNOT1, a core subunit of the CCR4-NOT complex. A high-resolution crystal structure of the TTP-CNOT1 complex was determined, providing the first structural insight, to our knowledge, into an ARE-binding protein bound to the CCR4-NOT complex. Mutations at the CNOT1-TTP interface impair TTP-mediated deadenylation, demonstrating the significance of this interaction in TTP-mediated gene silencing."xsd:string |
| http://purl.uniprot.org/citations/23644599 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb.2572"xsd:string |
| http://purl.uniprot.org/citations/23644599 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb.2572"xsd:string |
| http://purl.uniprot.org/citations/23644599 | http://purl.uniprot.org/core/author | "Blackshear P.J."xsd:string |
| http://purl.uniprot.org/citations/23644599 | http://purl.uniprot.org/core/author | "Blackshear P.J."xsd:string |
| http://purl.uniprot.org/citations/23644599 | http://purl.uniprot.org/core/author | "Fabian M.R."xsd:string |
| http://purl.uniprot.org/citations/23644599 | http://purl.uniprot.org/core/author | "Fabian M.R."xsd:string |
| http://purl.uniprot.org/citations/23644599 | http://purl.uniprot.org/core/author | "Frank F."xsd:string |
| http://purl.uniprot.org/citations/23644599 | http://purl.uniprot.org/core/author | "Frank F."xsd:string |
| http://purl.uniprot.org/citations/23644599 | http://purl.uniprot.org/core/author | "Sonenberg N."xsd:string |
| http://purl.uniprot.org/citations/23644599 | http://purl.uniprot.org/core/author | "Sonenberg N."xsd:string |
| http://purl.uniprot.org/citations/23644599 | http://purl.uniprot.org/core/author | "Siddiqui N."xsd:string |
| http://purl.uniprot.org/citations/23644599 | http://purl.uniprot.org/core/author | "Siddiqui N."xsd:string |
| http://purl.uniprot.org/citations/23644599 | http://purl.uniprot.org/core/author | "Nagar B."xsd:string |
| http://purl.uniprot.org/citations/23644599 | http://purl.uniprot.org/core/author | "Nagar B."xsd:string |
| http://purl.uniprot.org/citations/23644599 | http://purl.uniprot.org/core/author | "Lai W.S."xsd:string |
| http://purl.uniprot.org/citations/23644599 | http://purl.uniprot.org/core/author | "Lai W.S."xsd:string |
| http://purl.uniprot.org/citations/23644599 | http://purl.uniprot.org/core/author | "Karetnikov A."xsd:string |
| http://purl.uniprot.org/citations/23644599 | http://purl.uniprot.org/core/author | "Karetnikov A."xsd:string |
| http://purl.uniprot.org/citations/23644599 | http://purl.uniprot.org/core/author | "Rouya C."xsd:string |
| http://purl.uniprot.org/citations/23644599 | http://purl.uniprot.org/core/author | "Rouya C."xsd:string |
| http://purl.uniprot.org/citations/23644599 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23644599 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |