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The shared allelic architecture of adiponectin levels and coronary artery disease.

CARDIoGRAM Consortium

Dastani Z., Johnson T., Kronenberg F., Nelson C.P., Assimes T.L., Marz W., Richards J.B., Kathiresan S., Reilly M.P., Samani N.J., Schunkert H., Erdmann J., Assimes T.L., Boerwinkle E., Erdmann J., Hall A., Hengstenberg C., Kathiresan S., Konig I.R., Laaksonen R., McPherson R., Reilly M.P., Samani N.J., Schunkert H., Thompson J.R., Thorsteinsdottir U., Ziegler A., Konig I.R., Thompson J.R., Absher D., Chen L., Cupples L., Halperin E., Li M., Musunuru K., Preuss M., Schillert A., Thorleifsson G., Voight B.F., Wells G.A., Assimes T.L., Deloukas P., Erdmann J., Holm H., Kathiresan S., Konig I.R., McPherson R., Reilly M.P., Roberts R., Samani N.J., Schunkert H., Stewart A.F., Absher D., Assimes T.L., Fortmann S., Go A., Hlatky M., Iribarren C., Knowles J., Myers R., Quertermous T., Sidney S., Risch N., Tang H., Blankenberg S., Zeller T., Schillert A., Wild P., Ziegler A., Schnabel R., Sinning C., Lackner K., Tiret L., Nicaud V., Cambien F., Bickel C., Rupprecht H.J., Perret C., Proust C., Munzel T., Barbalic M., Bis J., Boerwinkle E., Chen I.Y., Cupples L., Dehghan A., Demissie-Banjaw S., Folsom A., Glazer N., Gudnason V., Harris T., Heckbert S., Levy D., Lumley T., Marciante K., Morrison A., O'Donnell C.J., Psaty B.M., Rice K., Rotter J.I., Siscovick D.S., Smith N., Smith A., Taylor K.D., van Duijn C., Volcik K., Whitteman J., Ramachandran V., Hofman A., Uitterlinden A., Gretarsdottir S., Gulcher J.R., Holm H., Kong A., Stefansson K., Thorgeirsson G., Andersen K., Thorleifsson G., Thorsteinsdottir U., Erdmann J., Fischer M., Hengstenberg C., Konig I.R., Lieb W., Stark K., Schreiber S., Wichmann H.-, Ziegler A., Schunkert H., Aherrahrou Z., Bruse P., Doering A., Erdmann J., Hengstenberg C., Illig T., Klopp N., Konig I.R., Loley C., Medack A., Meisinger C., Meitinger T., Nahrstaedt J., Peters A., Stark K., Wichmann H.-, Willenborg C., Ziegler A., Schunkert H., Bohm B.O., Dobnig H., Grammer T.B., Halperin E., Hoffmann M.M., Kleber M., Laaksonen R., Marz W., Meinitzer A., Winkelmann B.R., Pilz S., Renner W., Scharnagl H., Stojakovic T., Tomaschitz A., Winkler K., Voight B.F., Musunuru K., Guiducci C., Burtt N., Gabriel S.B., Siscovick D.S., O'Donnell C.J., Elosua R., Peltonen L., Salomaa V., Schwartz S.M., Melander O., Altshuler D., Kathiresan S., Stewart A.F., Chen L., Dandona S., Wells G.A., Jarinova O., McPherson R., Roberts R., Reilly M.P., Li M., Qu L., Wilensky R., Matthai W., Hakonarson H.H., Devaney J., Burnett M.S., Pichard A.D., Kent K.M., Satler L., Lindsay J.M., Waksman R., Knouff C.W., Waterworth D.M., Walker M.C., Mooser V., Epstein S.E., Rader D.J., Samani N.J., Thompson J.R., Braund P.S., Nelson C.P., Wright B.J., Balmforth A.J., Ball S.G., Hall A.S., Dastani Z., Hivert M.F., Timpson N., Perry J.R., Yuan X., Scott R.A., Henneman P., Heid I.M., Kizer J.R., Lyytikainen L.P., Fuchsberger C., Tanaka T., Morris A.P., Small K., Isaacs A., Beekman M., Coassin S., Lohman K., Qi L., Kanoni S., Pankow J.S., Uh H.W., Wu Y., Bidulescu A., Rasmussen-Torvik L.J., Greenwood C.M., Ladouceur M., Grimsby J., Manning A.K., Liu C.T., Kooner J., Mooser V.E., Vollenweider P., Kapur K.A., Chambers J., Wareham N.J., Langenberg C., Frants R., Willems-vanDijk K., Oostra B.A., Willems S.M., Lamina C., Winkler T.W., Psaty B.M., Tracy R.P., Brody J., Chen I., Viikari J., Kahonen M., Pramstaller P.P., Evans D.M., Pourcain B.S., Sattar N., Wood A.R., Bandinelli S., Carlson O.D., Egan J.M., Bohringer S., van Heemst D., Kedenko L., Kristiansson K., Nuotio M.L., Loo B.M., Harris T., Garcia M., Kanaya A., Haun M., Klopp N., Wichmann H., Deloukas P., Katsareli E., Couper D.J., Duncan B.B., Kloppenburg M., Adair L.S., Borja J.B., Wilson J.G., Musani S., Guo X., Johnson T., Semple R., Teslovich T.M., Allison M.A., Redline S., Buxbaum S.G., Mohlke K.L., Meulenbelt I., Ballantyne C.M., Dedoussis G.V., Hu F.B., Liu Y., Paulweber B., Spector T.D., Slagboom P., Ferrucci L., Jula A., Perola M., Raitakari O., Florez J.C., Salomaa V., Eriksson J.G., Frayling T.M., Hicks A.A., Lehtimaki T., Smith G.D., Siscovick D.S., Kronenberg F., van Duijn C., Loos R.J., Waterworth M., Meigs J.B., Dupuis J., Richards J.B.

OBJECTIVE:A large body of epidemiologic data strongly suggests an association between excess adiposity and coronary artery disease (CAD). Low adiponectin levels, a hormone secreted only from adipocytes, have been associated with an increased risk of CAD in observational studies. However, these associations cannot clarify whether this relationship is causal or due to a shared set of causal factors or even confounding. Genome-wide association studies have identified common variants that influence adiponectin levels, providing valuable tools to examine the genetic relationship between adiponectin and CAD. METHODS:Using 145 genome wide significant SNPs for adiponectin from the ADIPOGen consortium (n = 49,891), we tested whether adiponectin-decreasing alleles influenced risk of CAD in the CARDIoGRAM consortium (n = 85,274). RESULTS:In single-SNP analysis, 5 variants among 145 SNPs were associated with increased risk of CAD after correcting for multiple testing (P < 4.4 × 10(-4)). Using a multi-SNP genotypic risk score to test whether adiponectin levels and CAD have a shared genetic etiology, we found that adiponectin-decreasing alleles increased risk of CAD (P = 5.4 × 10(-7)). CONCLUSION:These findings demonstrate that adiponectin levels and CAD have a shared allelic architecture and provide rationale to undertake a Mendelian randomization studies to understand if this relationship is causal.

Atherosclerosis 229:145-148(2013) [PubMed] [Europe PMC]

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