| http://purl.uniprot.org/citations/23675531 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23675531 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23675531 | http://www.w3.org/2000/01/rdf-schema#comment | "NF-κB is a ubiquitously expressed transcription factor that regulates a large number of genes in response to diverse physiological and pathological stimuli. The regulation of the transcriptional activity of NF-κB is often dependent on its interaction with IκBα. Proteins that bind to IκBα are critical regulators of NF-κB activity. DDRGK1 is a member of the DDRGK domain-containing protein family with unknown function. In this study, we showed that the depletion of DDRGK1 inhibits cell proliferation and invasion. Microarray analysis indicated that the expression of NF-κB target genes showed the most significant decrease after depleting of DDRGK1, suggesting that DDRGK1 may play an important role in the NF-κB signaling pathway. We further demonstrated that DDRGK1 interacts with IκBα and regulates its stability, thereby regulates the NF-κB transcriptional activity. Our findings identify DDRGK1 as an important regulator of the NF-κB pathway."xsd:string |
| http://purl.uniprot.org/citations/23675531 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0064231"xsd:string |
| http://purl.uniprot.org/citations/23675531 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0064231"xsd:string |
| http://purl.uniprot.org/citations/23675531 | http://purl.uniprot.org/core/author | "Zhou J."xsd:string |
| http://purl.uniprot.org/citations/23675531 | http://purl.uniprot.org/core/author | "Zhou J."xsd:string |
| http://purl.uniprot.org/citations/23675531 | http://purl.uniprot.org/core/author | "Wang M."xsd:string |
| http://purl.uniprot.org/citations/23675531 | http://purl.uniprot.org/core/author | "Wang M."xsd:string |
| http://purl.uniprot.org/citations/23675531 | http://purl.uniprot.org/core/author | "Ding D."xsd:string |
| http://purl.uniprot.org/citations/23675531 | http://purl.uniprot.org/core/author | "Ding D."xsd:string |
| http://purl.uniprot.org/citations/23675531 | http://purl.uniprot.org/core/author | "Cong Y.S."xsd:string |
| http://purl.uniprot.org/citations/23675531 | http://purl.uniprot.org/core/author | "Cong Y.S."xsd:string |
| http://purl.uniprot.org/citations/23675531 | http://purl.uniprot.org/core/author | "Xi P."xsd:string |
| http://purl.uniprot.org/citations/23675531 | http://purl.uniprot.org/core/author | "Xi P."xsd:string |
| http://purl.uniprot.org/citations/23675531 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23675531 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23675531 | http://purl.uniprot.org/core/name | "PLoS ONE"xsd:string |
| http://purl.uniprot.org/citations/23675531 | http://purl.uniprot.org/core/name | "PLoS ONE"xsd:string |
| http://purl.uniprot.org/citations/23675531 | http://purl.uniprot.org/core/pages | "E64231"xsd:string |
| http://purl.uniprot.org/citations/23675531 | http://purl.uniprot.org/core/pages | "E64231"xsd:string |
| http://purl.uniprot.org/citations/23675531 | http://purl.uniprot.org/core/title | "DDRGK1 regulates NF-kappaB activity by modulating IkappaBalpha stability."xsd:string |
| http://purl.uniprot.org/citations/23675531 | http://purl.uniprot.org/core/title | "DDRGK1 regulates NF-kappaB activity by modulating IkappaBalpha stability."xsd:string |
| http://purl.uniprot.org/citations/23675531 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/23675531 | http://purl.uniprot.org/core/volume | "8"xsd:string |