| http://purl.uniprot.org/citations/23706741 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23706741 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23706741 | http://www.w3.org/2000/01/rdf-schema#comment | "Regnase-1 (also known as Zc3h12a and MCPIP1) is an RNase that destabilizes a set of mRNAs, including Il6 and Il12b, through cleavage of their 3' UTRs. Although Regnase-1 inactivation leads to development of an autoimmune disease characterized by T cell activation and hyperimmunoglobulinemia in mice, the mechanism of Regnase-1-mediated immune regulation has remained unclear. We show that Regnase-1 is essential for preventing aberrant effector CD4(+) T cell generation cell autonomously. Moreover, in T cells, Regnase-1 regulates the mRNAs of a set of genes, including c-Rel, Ox40, and Il2, through cleavage of their 3' UTRs. Interestingly, T cell receptor (TCR) stimulation leads to cleavage of Regnase-1 at R111 by Malt1/paracaspase, freeing T cells from Regnase-1-mediated suppression. Furthermore, Malt1 protease activity is critical for controlling the mRNA stability of T cell effector genes. Collectively, these results indicate that dynamic control of Regnase-1 expression in T cells is critical for controlling T cell activation."xsd:string |
| http://purl.uniprot.org/citations/23706741 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2013.04.034"xsd:string |
| http://purl.uniprot.org/citations/23706741 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2013.04.034"xsd:string |
| http://purl.uniprot.org/citations/23706741 | http://purl.uniprot.org/core/author | "Iwasaki H."xsd:string |
| http://purl.uniprot.org/citations/23706741 | http://purl.uniprot.org/core/author | "Iwasaki H."xsd:string |
| http://purl.uniprot.org/citations/23706741 | http://purl.uniprot.org/core/author | "Matsushita K."xsd:string |
| http://purl.uniprot.org/citations/23706741 | http://purl.uniprot.org/core/author | "Matsushita K."xsd:string |
| http://purl.uniprot.org/citations/23706741 | http://purl.uniprot.org/core/author | "Suzuki Y."xsd:string |
| http://purl.uniprot.org/citations/23706741 | http://purl.uniprot.org/core/author | "Suzuki Y."xsd:string |
| http://purl.uniprot.org/citations/23706741 | http://purl.uniprot.org/core/author | "Satoh T."xsd:string |
| http://purl.uniprot.org/citations/23706741 | http://purl.uniprot.org/core/author | "Satoh T."xsd:string |
| http://purl.uniprot.org/citations/23706741 | http://purl.uniprot.org/core/author | "Akira S."xsd:string |
| http://purl.uniprot.org/citations/23706741 | http://purl.uniprot.org/core/author | "Akira S."xsd:string |
| http://purl.uniprot.org/citations/23706741 | http://purl.uniprot.org/core/author | "Tsujimura T."xsd:string |
| http://purl.uniprot.org/citations/23706741 | http://purl.uniprot.org/core/author | "Tsujimura T."xsd:string |
| http://purl.uniprot.org/citations/23706741 | http://purl.uniprot.org/core/author | "Standley D.M."xsd:string |
| http://purl.uniprot.org/citations/23706741 | http://purl.uniprot.org/core/author | "Standley D.M."xsd:string |
| http://purl.uniprot.org/citations/23706741 | http://purl.uniprot.org/core/author | "Mino T."xsd:string |
| http://purl.uniprot.org/citations/23706741 | http://purl.uniprot.org/core/author | "Mino T."xsd:string |
| http://purl.uniprot.org/citations/23706741 | http://purl.uniprot.org/core/author | "Takeuchi O."xsd:string |
| http://purl.uniprot.org/citations/23706741 | http://purl.uniprot.org/core/author | "Takeuchi O."xsd:string |
| http://purl.uniprot.org/citations/23706741 | http://purl.uniprot.org/core/author | "Vandenbon A."xsd:string |
| http://purl.uniprot.org/citations/23706741 | http://purl.uniprot.org/core/author | "Vandenbon A."xsd:string |