| http://purl.uniprot.org/citations/23775122 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23775122 | http://www.w3.org/2000/01/rdf-schema#comment | "Protein kinase C (PKC) activation, induced by hyperglycemia and angiotensin II (AngII), inhibited insulin-induced phosphorylation of Akt/endothelial nitric oxide (eNOS) by decreasing tyrosine phosphorylation of IRS2 (p-Tyr-IRS2) in endothelial cells. PKC activation by phorbol ester (phorbol myristate acetate [PMA]) reduced insulin-induced p-Tyr-IRS2 by 46% ± 13% and, similarly, phosphorylation of Akt/eNOS. Site-specific mutational analysis showed that PMA increased serine phosphorylation at three sites on IRS2 (positions 303, 343, and 675), which affected insulin-induced tyrosine phosphorylation of IRS2 at positions 653, 671, and 911 (p-Tyr-IRS2) and p-Akt/eNOS. Specific PKCβ2 activation decreased p-Tyr-IRS2 and increased the phosphorylation of two serines (Ser303 and Ser675) on IRS2 that were confirmed in cells overexpressing single point mutants of IRS2 (S303A or S675A) containing a PKCβ2-dominant negative or selective PKCβ inhibitor. AngII induced phosphorylation only on Ser303 of IRS2 and inhibited insulin-induced p-Tyr911 of IRS2 and p-Akt/eNOS, which were blocked by an antagonist of AngII receptor I, losartan, or overexpression of single mutant S303A of IRS2. Increases in p-Ser303 and p-Ser675 and decreases in p-Tyr911 of IRS2 were observed in vessels of insulin-resistant Zucker fatty rats versus lean rats. Thus, AngII or PKCβ activation can phosphorylate Ser303 and Ser675 in IRS2 to inhibit insulin-induced p-Tyr911 and its anti-atherogenic actions (p-Akt/eNOS) in endothelial cells."xsd:string |
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| http://purl.uniprot.org/citations/23775122 | http://purl.uniprot.org/core/author | "Li Q."xsd:string |
| http://purl.uniprot.org/citations/23775122 | http://purl.uniprot.org/core/author | "Maeda Y."xsd:string |
| http://purl.uniprot.org/citations/23775122 | http://purl.uniprot.org/core/author | "Park K."xsd:string |
| http://purl.uniprot.org/citations/23775122 | http://purl.uniprot.org/core/author | "White M.F."xsd:string |
| http://purl.uniprot.org/citations/23775122 | http://purl.uniprot.org/core/author | "Mizutani K."xsd:string |
| http://purl.uniprot.org/citations/23775122 | http://purl.uniprot.org/core/author | "King G.L."xsd:string |
| http://purl.uniprot.org/citations/23775122 | http://purl.uniprot.org/core/author | "Feener E.P."xsd:string |
| http://purl.uniprot.org/citations/23775122 | http://purl.uniprot.org/core/author | "Rask-Madsen C."xsd:string |
| http://purl.uniprot.org/citations/23775122 | http://purl.uniprot.org/core/author | "Winnay J."xsd:string |
| http://purl.uniprot.org/citations/23775122 | http://purl.uniprot.org/core/author | "Mima A."xsd:string |
| http://purl.uniprot.org/citations/23775122 | http://purl.uniprot.org/core/author | "D'Aquino K."xsd:string |
| http://purl.uniprot.org/citations/23775122 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23775122 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/23775122 | http://purl.uniprot.org/core/pages | "3227-3241"xsd:string |
| http://purl.uniprot.org/citations/23775122 | http://purl.uniprot.org/core/title | "Serine phosphorylation sites on IRS2 activated by angiotensin II and protein kinase C to induce selective insulin resistance in endothelial cells."xsd:string |
| http://purl.uniprot.org/citations/23775122 | http://purl.uniprot.org/core/volume | "33"xsd:string |
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