| http://purl.uniprot.org/citations/23792023 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23792023 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23792023 | http://www.w3.org/2000/01/rdf-schema#comment | "The SRY-related HMG box transcription factor Sox2 plays critical roles throughout embryogenesis. Haploinsufficiency for SOX2 results in human developmental defects including anophthalmia, microphthalmia and septo-optic dysplasia, a congenital forebrain defect. To understand how Sox2 plays a role in neurogenesis, we combined genomic and in vivo transgenic approaches to characterize genomic regions occupied by Sox2 in the developing forebrain. Six3, a homeobox gene associated with holoprosencephaly, a forebrain midline defect, was identified as a Sox2 transcriptional target. This study shows that Sox2 directly regulates a previously unidentified long-range forebrain enhancer to activate Six3 expression in the rostral diencephalon. Further biochemical and genetic evidences indicated a direct regulatory link between Sox2 and Six3 during forebrain development, providing a better understanding of a common molecular mechanism underlying these forebrain defects."xsd:string |
| http://purl.uniprot.org/citations/23792023 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ydbio.2013.06.016"xsd:string |
| http://purl.uniprot.org/citations/23792023 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ydbio.2013.06.016"xsd:string |
| http://purl.uniprot.org/citations/23792023 | http://purl.uniprot.org/core/author | "Song H."xsd:string |
| http://purl.uniprot.org/citations/23792023 | http://purl.uniprot.org/core/author | "Song H."xsd:string |
| http://purl.uniprot.org/citations/23792023 | http://purl.uniprot.org/core/author | "Lee B."xsd:string |
| http://purl.uniprot.org/citations/23792023 | http://purl.uniprot.org/core/author | "Lee B."xsd:string |
| http://purl.uniprot.org/citations/23792023 | http://purl.uniprot.org/core/author | "Baek K."xsd:string |
| http://purl.uniprot.org/citations/23792023 | http://purl.uniprot.org/core/author | "Baek K."xsd:string |
| http://purl.uniprot.org/citations/23792023 | http://purl.uniprot.org/core/author | "Yoon J."xsd:string |
| http://purl.uniprot.org/citations/23792023 | http://purl.uniprot.org/core/author | "Yoon J."xsd:string |
| http://purl.uniprot.org/citations/23792023 | http://purl.uniprot.org/core/author | "Rizzoti K."xsd:string |
| http://purl.uniprot.org/citations/23792023 | http://purl.uniprot.org/core/author | "Rizzoti K."xsd:string |
| http://purl.uniprot.org/citations/23792023 | http://purl.uniprot.org/core/author | "Jeong Y."xsd:string |
| http://purl.uniprot.org/citations/23792023 | http://purl.uniprot.org/core/author | "Jeong Y."xsd:string |
| http://purl.uniprot.org/citations/23792023 | http://purl.uniprot.org/core/author | "Son Y."xsd:string |
| http://purl.uniprot.org/citations/23792023 | http://purl.uniprot.org/core/author | "Son Y."xsd:string |
| http://purl.uniprot.org/citations/23792023 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23792023 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23792023 | http://purl.uniprot.org/core/name | "Dev. Biol."xsd:string |
| http://purl.uniprot.org/citations/23792023 | http://purl.uniprot.org/core/name | "Dev. Biol."xsd:string |
| http://purl.uniprot.org/citations/23792023 | http://purl.uniprot.org/core/pages | "491-501"xsd:string |
| http://purl.uniprot.org/citations/23792023 | http://purl.uniprot.org/core/pages | "491-501"xsd:string |