| http://purl.uniprot.org/citations/23793062 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23793062 | http://www.w3.org/2000/01/rdf-schema#comment | "Although T cell activation can result from signaling via T cell antigen receptor (TCR) alone, physiological T cell responses require costimulation via the coreceptor CD28. Through the use of an N-ethyl-N-nitrosourea-mutagenesis screen, we identified a mutation in Rltpr. We found that Rltpr was a lymphoid cell-specific, actin-uncapping protein essential for costimulation via CD28 and the development of regulatory T cells. Engagement of TCR-CD28 at the immunological synapse resulted in the colocalization of CD28 with both wild-type and mutant Rltpr proteins. However, the connection between CD28 and protein kinase C-θ and Carma1, two key effectors of CD28 costimulation, was abrogated in T cells expressing mutant Rltpr, and CD28 costimulation did not occur in those cells. Our findings provide a more complete model of CD28 costimulation in which Rltpr has a key role."xsd:string |
| http://purl.uniprot.org/citations/23793062 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni.2634"xsd:string |
| http://purl.uniprot.org/citations/23793062 | http://purl.uniprot.org/core/author | "Liang Y."xsd:string |
| http://purl.uniprot.org/citations/23793062 | http://purl.uniprot.org/core/author | "Saito T."xsd:string |
| http://purl.uniprot.org/citations/23793062 | http://purl.uniprot.org/core/author | "Nijman I.J."xsd:string |
| http://purl.uniprot.org/citations/23793062 | http://purl.uniprot.org/core/author | "Imbert J."xsd:string |
| http://purl.uniprot.org/citations/23793062 | http://purl.uniprot.org/core/author | "Yokosuka T."xsd:string |
| http://purl.uniprot.org/citations/23793062 | http://purl.uniprot.org/core/author | "Cucchetti M."xsd:string |
| http://purl.uniprot.org/citations/23793062 | http://purl.uniprot.org/core/author | "Malissen B."xsd:string |
| http://purl.uniprot.org/citations/23793062 | http://purl.uniprot.org/core/author | "Malissen M."xsd:string |
| http://purl.uniprot.org/citations/23793062 | http://purl.uniprot.org/core/author | "Roncagalli R."xsd:string |
| http://purl.uniprot.org/citations/23793062 | http://purl.uniprot.org/core/author | "Suchanek M."xsd:string |
| http://purl.uniprot.org/citations/23793062 | http://purl.uniprot.org/core/author | "Malzac A."xsd:string |
| http://purl.uniprot.org/citations/23793062 | http://purl.uniprot.org/core/author | "Bertosio E."xsd:string |
| http://purl.uniprot.org/citations/23793062 | http://purl.uniprot.org/core/author | "Wulfing C."xsd:string |
| http://purl.uniprot.org/citations/23793062 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23793062 | http://purl.uniprot.org/core/name | "Nat Immunol"xsd:string |
| http://purl.uniprot.org/citations/23793062 | http://purl.uniprot.org/core/pages | "858-866"xsd:string |
| http://purl.uniprot.org/citations/23793062 | http://purl.uniprot.org/core/title | "The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells."xsd:string |
| http://purl.uniprot.org/citations/23793062 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/23793062 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23793062 |
| http://purl.uniprot.org/citations/23793062 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23793062 |
| http://purl.uniprot.org/uniprot/P12023#attribution-FB4D9493A899449A214CEB566466322E | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23793062 |
| http://purl.uniprot.org/uniprot/P31750#attribution-FB4D9493A899449A214CEB566466322E | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23793062 |