| http://purl.uniprot.org/citations/23878390 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23878390 | http://www.w3.org/2000/01/rdf-schema#comment | "CD146, an endothelial biomarker, has been shown to be aberrantly upregulated during pathological angiogenesis and functions as a coreceptor for vascular endothelial growth factor receptor 2 (VEGFR-2) to promote disease progression. However, the regulatory mechanisms of CD146 expression during angiogenesis remain unclear. Using a microRNA screening approach, we identified a novel negative regulator of angiogenesis, microRNA 329 (miR-329), that directly targeted CD146 and inhibited CD146-mediated angiogenesis in vitro and in vivo. Endogenous miR-329 expression was downregulated by VEGF and tumor necrosis factor alpha (TNF-α), resulting in the elevation of CD146 in endothelial cells. Upregulation of CD146 facilitated an endothelial response to VEGF-induced SRC kinase family (SKF)/p38 mitogen-activated protein kinase (MAPK)/NF-κB activation and consequently promoted endothelial cell migration and tube formation. Our animal experiments showed that treatment with miR-329 repressed excessive CD146 expression on blood vessels and significantly attenuated neovascularization in a mouse model of pathological angiogenesis. Our findings provide the first evidence that CD146 expression in angiogenesis is regulated by miR-329 and suggest that miR-329 could present a potential therapeutic tool for the treatment of angiogenic diseases."xsd:string |
| http://purl.uniprot.org/citations/23878390 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.00343-13"xsd:string |
| http://purl.uniprot.org/citations/23878390 | http://purl.uniprot.org/core/author | "Luo Y."xsd:string |
| http://purl.uniprot.org/citations/23878390 | http://purl.uniprot.org/core/author | "Lu D."xsd:string |
| http://purl.uniprot.org/citations/23878390 | http://purl.uniprot.org/core/author | "Song L."xsd:string |
| http://purl.uniprot.org/citations/23878390 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/23878390 | http://purl.uniprot.org/core/author | "Yang D."xsd:string |
| http://purl.uniprot.org/citations/23878390 | http://purl.uniprot.org/core/author | "Wang P."xsd:string |
| http://purl.uniprot.org/citations/23878390 | http://purl.uniprot.org/core/author | "Yan X."xsd:string |
| http://purl.uniprot.org/citations/23878390 | http://purl.uniprot.org/core/author | "Feng J."xsd:string |
| http://purl.uniprot.org/citations/23878390 | http://purl.uniprot.org/core/author | "Duan H."xsd:string |
| http://purl.uniprot.org/citations/23878390 | http://purl.uniprot.org/core/author | "Xing S."xsd:string |
| http://purl.uniprot.org/citations/23878390 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23878390 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/23878390 | http://purl.uniprot.org/core/pages | "3689-3699"xsd:string |
| http://purl.uniprot.org/citations/23878390 | http://purl.uniprot.org/core/title | "MicroRNA 329 suppresses angiogenesis by targeting CD146."xsd:string |
| http://purl.uniprot.org/citations/23878390 | http://purl.uniprot.org/core/volume | "33"xsd:string |
| http://purl.uniprot.org/citations/23878390 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23878390 |
| http://purl.uniprot.org/citations/23878390 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23878390 |
| http://purl.uniprot.org/uniprot/P43121#attribution-6BE21B868889CA23863FCC1C6A42AFA6 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23878390 |
| http://purl.uniprot.org/uniprot/P01375#attribution-109932D7786450721F02B4B663947A1D | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23878390 |
| http://purl.uniprot.org/uniprot/Q04206#attribution-D8453361F2184FB630DA4DB98CC18350 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23878390 |
| http://purl.uniprot.org/uniprot/P15692#attribution-109932D7786450721F02B4B663947A1D | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23878390 |
| http://purl.uniprot.org/uniprot/#_A0A1L1SQC5-mappedCitation-23878390 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23878390 |