| http://purl.uniprot.org/citations/23958951 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23958951 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23958951 | http://www.w3.org/2000/01/rdf-schema#comment | "With an array of activating and inhibitory receptors, natural killer (NK) cells are involved in the eradication of infected, transformed, and tumor cells. NKp44 is a member of the natural cytotoxicity receptor family, which is exclusively expressed on activated NK cells. Here, we identify natural cytotoxicity receptor NKp44 (NKp44L), a novel isoform of the mixed-lineage leukemia-5 protein, as a cellular ligand for NKp44. Unlike the other MLL family members, NKp44L is excluded from the nucleus, but expressed at the cell-surface level; its subcellular localization is being associated with the presence of a specific C-terminal motif. Strikingly, NKp44L has not been detected on circulating cells isolated from healthy individuals, but it is expressed on a large panel of the tumor and transformed cells. The sharply decreased NK lysis activity induced by anti-NKp44L antibodies directly demonstrates the role of NKp44L in cytotoxicity. Taken together, these results show that NKp44L could be critical for NK cell-mediated innate immunity. The identification and cellular distribution of NKp44L highlight the role of this self-molecule as a danger signal to alert the NK cell network."xsd:string |
| http://purl.uniprot.org/citations/23958951 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2013-03-489054"xsd:string |
| http://purl.uniprot.org/citations/23958951 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2013-03-489054"xsd:string |
| http://purl.uniprot.org/citations/23958951 | http://purl.uniprot.org/core/author | "Ermonval M."xsd:string |
| http://purl.uniprot.org/citations/23958951 | http://purl.uniprot.org/core/author | "Ermonval M."xsd:string |
| http://purl.uniprot.org/citations/23958951 | http://purl.uniprot.org/core/author | "Debre P."xsd:string |
| http://purl.uniprot.org/citations/23958951 | http://purl.uniprot.org/core/author | "Debre P."xsd:string |
| http://purl.uniprot.org/citations/23958951 | http://purl.uniprot.org/core/author | "Dorgham K."xsd:string |
| http://purl.uniprot.org/citations/23958951 | http://purl.uniprot.org/core/author | "Dorgham K."xsd:string |
| http://purl.uniprot.org/citations/23958951 | http://purl.uniprot.org/core/author | "Baychelier F."xsd:string |
| http://purl.uniprot.org/citations/23958951 | http://purl.uniprot.org/core/author | "Baychelier F."xsd:string |
| http://purl.uniprot.org/citations/23958951 | http://purl.uniprot.org/core/author | "Sennepin A."xsd:string |
| http://purl.uniprot.org/citations/23958951 | http://purl.uniprot.org/core/author | "Sennepin A."xsd:string |
| http://purl.uniprot.org/citations/23958951 | http://purl.uniprot.org/core/author | "Vieillard V."xsd:string |
| http://purl.uniprot.org/citations/23958951 | http://purl.uniprot.org/core/author | "Vieillard V."xsd:string |
| http://purl.uniprot.org/citations/23958951 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23958951 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23958951 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/23958951 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/23958951 | http://purl.uniprot.org/core/pages | "2935-2942"xsd:string |
| http://purl.uniprot.org/citations/23958951 | http://purl.uniprot.org/core/pages | "2935-2942"xsd:string |
| http://purl.uniprot.org/citations/23958951 | http://purl.uniprot.org/core/title | "Identification of a cellular ligand for the natural cytotoxicity receptor NKp44."xsd:string |
| http://purl.uniprot.org/citations/23958951 | http://purl.uniprot.org/core/title | "Identification of a cellular ligand for the natural cytotoxicity receptor NKp44."xsd:string |