| http://purl.uniprot.org/citations/23989952 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23989952 | http://www.w3.org/2000/01/rdf-schema#comment | "Signaling pathways are reused for multiple purposes in plant and animal development. The Hippo pathway in mammals and Drosophila coordinates proliferation and apoptosis via the coactivator and oncoprotein YAP/Yorkie (Yki), which is homeostatically regulated through negative feedback. In the Drosophila eye, cross-repression between the Hippo pathway kinase LATS/Warts (Wts) and growth regulator Melted generates mutually exclusive photoreceptor subtypes. Here, we show that this all-or-nothing neuronal differentiation results from Hippo pathway positive feedback: Yki both represses its negative regulator, warts, and promotes its positive regulator, melted. This postmitotic Hippo network behavior relies on a tissue-restricted transcription factor network-including a conserved Otx/Orthodenticle-Nrl/Traffic Jam feedforward module-that allows Warts-Yki-Melted to operate as a bistable switch. Altering feedback architecture provides an efficient mechanism to co-opt conserved signaling networks for diverse purposes in development and evolution."xsd:string |
| http://purl.uniprot.org/citations/23989952 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1238016"xsd:string |
| http://purl.uniprot.org/citations/23989952 | http://purl.uniprot.org/core/author | "Xie B."xsd:string |
| http://purl.uniprot.org/citations/23989952 | http://purl.uniprot.org/core/author | "Cook T."xsd:string |
| http://purl.uniprot.org/citations/23989952 | http://purl.uniprot.org/core/author | "Gebelein B."xsd:string |
| http://purl.uniprot.org/citations/23989952 | http://purl.uniprot.org/core/author | "Desplan C."xsd:string |
| http://purl.uniprot.org/citations/23989952 | http://purl.uniprot.org/core/author | "Terrell D."xsd:string |
| http://purl.uniprot.org/citations/23989952 | http://purl.uniprot.org/core/author | "Pistillo D."xsd:string |
| http://purl.uniprot.org/citations/23989952 | http://purl.uniprot.org/core/author | "Rister J."xsd:string |
| http://purl.uniprot.org/citations/23989952 | http://purl.uniprot.org/core/author | "Jukam D."xsd:string |
| http://purl.uniprot.org/citations/23989952 | http://purl.uniprot.org/core/author | "Charlton-Perkins M."xsd:string |
| http://purl.uniprot.org/citations/23989952 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23989952 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/23989952 | http://purl.uniprot.org/core/pages | "1238016"xsd:string |
| http://purl.uniprot.org/citations/23989952 | http://purl.uniprot.org/core/title | "Opposite feedbacks in the Hippo pathway for growth control and neural fate."xsd:string |
| http://purl.uniprot.org/citations/23989952 | http://purl.uniprot.org/core/volume | "342"xsd:string |
| http://purl.uniprot.org/citations/23989952 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23989952 |
| http://purl.uniprot.org/citations/23989952 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23989952 |
| http://purl.uniprot.org/uniprot/Q9VS24#attribution-81F132B36965CE4870BD0C05651D32A8 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23989952 |
| http://purl.uniprot.org/uniprot/Q9VA38#attribution-81F132B36965CE4870BD0C05651D32A8 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23989952 |
| http://purl.uniprot.org/uniprot/Q45VV3#attribution-81F132B36965CE4870BD0C05651D32A8 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23989952 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KFW0-mappedCitation-23989952 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23989952 |
| http://purl.uniprot.org/uniprot/#_A0A0C4DHD4-mappedCitation-23989952 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23989952 |
| http://purl.uniprot.org/uniprot/#_A0A0B4JDB7-mappedCitation-23989952 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23989952 |