| http://purl.uniprot.org/citations/24089527 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24089527 | http://www.w3.org/2000/01/rdf-schema#comment | "Caveolin-1 (Cav-1) interacts with and mediates protein trafficking and various cellular functions. Derlin-1 is a candidate for the retrotranslocation channel of endoplasmic reticulum proteins. However, little is known about how Derlin-1 mediates glycosylated protein degradation. Here, we identified Cav-1 as a key player in Derlin-1- and p97-mediated cyclooxygenase 2 (COX-2) ubiquitination and degradation. Derlin-1 augmented the interaction of Cav-1 and COX-2 and mediated the degradation of COX-2 in a COX-2 C terminus-dependent manner. Suppression of Cav-1 decreased the ubiquitination of COX-2, and mutation of Asn-594 to Ala to disrupt N-glycosylation at the C terminus of COX-2 reduced the interaction of COX-2 with Cav-1 but not Derlin-1. Moreover, suppression of p97 increased the ubiquitination of COX-2 and up-regulated COX-2 but not COX-1. Cav-1 enhanced the interaction of p97 with Ufd1 and Derlin-1 and collaborated with p97 to interact with COX-2. Cav-1 may be a cofactor in the interaction of Derlin-1 and N-glycosylated COX-2 and may facilitate Derlin-1- and p97 complex-mediated COX-2 ubiquitination, retrotranslocation, and degradation."xsd:string |
| http://purl.uniprot.org/citations/24089527 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m113.521799"xsd:string |
| http://purl.uniprot.org/citations/24089527 | http://purl.uniprot.org/core/author | "Tsai Y.C."xsd:string |
| http://purl.uniprot.org/citations/24089527 | http://purl.uniprot.org/core/author | "Lee Y.M."xsd:string |
| http://purl.uniprot.org/citations/24089527 | http://purl.uniprot.org/core/author | "Liou J.Y."xsd:string |
| http://purl.uniprot.org/citations/24089527 | http://purl.uniprot.org/core/author | "Tam K."xsd:string |
| http://purl.uniprot.org/citations/24089527 | http://purl.uniprot.org/core/author | "Wu C.H."xsd:string |
| http://purl.uniprot.org/citations/24089527 | http://purl.uniprot.org/core/author | "Chen S.F."xsd:string |
| http://purl.uniprot.org/citations/24089527 | http://purl.uniprot.org/core/author | "Shyue S.K."xsd:string |
| http://purl.uniprot.org/citations/24089527 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24089527 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/24089527 | http://purl.uniprot.org/core/pages | "33462-33469"xsd:string |
| http://purl.uniprot.org/citations/24089527 | http://purl.uniprot.org/core/title | "Caveolin-1 interacts with Derlin-1 and promotes ubiquitination and degradation of cyclooxygenase-2 via collaboration with p97 complex."xsd:string |
| http://purl.uniprot.org/citations/24089527 | http://purl.uniprot.org/core/volume | "288"xsd:string |
| http://purl.uniprot.org/citations/24089527 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24089527 |
| http://purl.uniprot.org/citations/24089527 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24089527 |
| http://purl.uniprot.org/uniprot/Q03135#attribution-263C04A7CAABE6C95A45D181A3676B2C | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24089527 |
| http://purl.uniprot.org/uniprot/Q03135#attribution-66857EAC68C14582AF9D8613E4D96F94 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24089527 |
| http://purl.uniprot.org/uniprot/Q03135#attribution-6E99C1CF61175F907CE4B729C5E8D813 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24089527 |
| http://purl.uniprot.org/uniprot/Q9BUN8#attribution-6E99C1CF61175F907CE4B729C5E8D813 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24089527 |
| http://purl.uniprot.org/uniprot/Q9BUN8#attribution-9FCBB63BB2C907DEBE0BEF6657EAD438 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24089527 |
| http://purl.uniprot.org/uniprot/P35354#attribution-66857EAC68C14582AF9D8613E4D96F94 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24089527 |
| http://purl.uniprot.org/uniprot/P35354#attribution-9FCBB63BB2C907DEBE0BEF6657EAD438 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24089527 |
| http://purl.uniprot.org/uniprot/P55072#attribution-6E99C1CF61175F907CE4B729C5E8D813 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24089527 |