| http://purl.uniprot.org/citations/24095731 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24095731 | http://www.w3.org/2000/01/rdf-schema#comment | "Telomeres are protected from nonhomologous end-joining (NHEJ) to avoid deleterious chromosome fusions, yet they associate with the Ku heterodimer that is principal in the classical NHEJ (c-NHEJ) pathway. T-loops have been proposed to inhibit Ku's association with telomeric ends, thus inhibiting c-NHEJ; however, deficiencies in the t-loop model suggest additional mechanisms are in effect. We demonstrate that TRF2 interacts with Ku at telomeres and via residues in Ku70 helix 5 (α5), which are vital for NHEJ. We show that Ku's interaction with a TRF2 mutant that induces telomeric fusions is significantly impaired. Additionally, we demonstrate that Ku70 α5 is required for Ku self-association in live cells, which can bridge DNA ends. Together, these findings lead us to propose a model in which telomeres are directly protected from c-NHEJ via TRF2 impeding Ku's ability to synapse telomere ends."xsd:string |
| http://purl.uniprot.org/citations/24095731 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2013.08.040"xsd:string |
| http://purl.uniprot.org/citations/24095731 | http://purl.uniprot.org/core/author | "Bertuch A.A."xsd:string |
| http://purl.uniprot.org/citations/24095731 | http://purl.uniprot.org/core/author | "Williams C.L."xsd:string |
| http://purl.uniprot.org/citations/24095731 | http://purl.uniprot.org/core/author | "Mihalek I."xsd:string |
| http://purl.uniprot.org/citations/24095731 | http://purl.uniprot.org/core/author | "Ribes-Zamora A."xsd:string |
| http://purl.uniprot.org/citations/24095731 | http://purl.uniprot.org/core/author | "Indiviglio S.M."xsd:string |
| http://purl.uniprot.org/citations/24095731 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24095731 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/24095731 | http://purl.uniprot.org/core/pages | "194-206"xsd:string |
| http://purl.uniprot.org/citations/24095731 | http://purl.uniprot.org/core/title | "TRF2 interaction with Ku heterotetramerization interface gives insight into c-NHEJ prevention at human telomeres."xsd:string |
| http://purl.uniprot.org/citations/24095731 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/24095731 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24095731 |
| http://purl.uniprot.org/citations/24095731 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24095731 |
| http://purl.uniprot.org/uniprot/Q15554#attribution-532208B87CE2E899FB4FA729092B0213 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24095731 |
| http://purl.uniprot.org/uniprot/P12956#attribution-92E60FD40894D3DFDD4356A60F2D2937 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24095731 |
| http://purl.uniprot.org/uniprot/P13010#attribution-C63AEE2E12AA0EF48F0D6CCDD47093C5 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24095731 |
| http://purl.uniprot.org/uniprot/#_Q15554-mappedCitation-24095731 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24095731 |
| http://purl.uniprot.org/uniprot/Q15554 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24095731 |