| http://purl.uniprot.org/citations/24130829 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24130829 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24130829 | http://www.w3.org/2000/01/rdf-schema#comment | "Mixed Lineage Leukemia 5 (MLL5) is a histone methyltransferase that plays a key role in hematopoiesis, spermatogenesis and cell cycle progression. In addition to its catalytic domain, MLL5 contains a PHD finger domain, a protein module that is often involved in binding to the N-terminus of histone H3. Here we report the NMR solution structure of the MLL5 PHD domain showing a variant of the canonical PHD fold that combines conserved H3 binding features from several classes of other PHD domains (including an aromatic cage) along with a novel C-terminal α-helix, not previously seen. We further demonstrate that the PHD domain binds with similar affinity to histone H3 tail peptides di- and tri-methylated at lysine 4 (H3K4me2 and H3K4me3), the former being the putative product of the MLL5 catalytic reaction. This work establishes the PHD domain of MLL5 as a bone fide 'reader' domain of H3K4 methyl marks suggesting that it may guide the spreading or further methylation of this site on chromatin."xsd:string |
| http://purl.uniprot.org/citations/24130829 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0077020"xsd:string |
| http://purl.uniprot.org/citations/24130829 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0077020"xsd:string |
| http://purl.uniprot.org/citations/24130829 | http://purl.uniprot.org/core/author | "Arrowsmith C.H."xsd:string |
| http://purl.uniprot.org/citations/24130829 | http://purl.uniprot.org/core/author | "Arrowsmith C.H."xsd:string |
| http://purl.uniprot.org/citations/24130829 | http://purl.uniprot.org/core/author | "Wu H."xsd:string |
| http://purl.uniprot.org/citations/24130829 | http://purl.uniprot.org/core/author | "Wu H."xsd:string |
| http://purl.uniprot.org/citations/24130829 | http://purl.uniprot.org/core/author | "Zeng H."xsd:string |
| http://purl.uniprot.org/citations/24130829 | http://purl.uniprot.org/core/author | "Zeng H."xsd:string |
| http://purl.uniprot.org/citations/24130829 | http://purl.uniprot.org/core/author | "Yee A."xsd:string |
| http://purl.uniprot.org/citations/24130829 | http://purl.uniprot.org/core/author | "Yee A."xsd:string |
| http://purl.uniprot.org/citations/24130829 | http://purl.uniprot.org/core/author | "Aparicio S."xsd:string |
| http://purl.uniprot.org/citations/24130829 | http://purl.uniprot.org/core/author | "Aparicio S."xsd:string |
| http://purl.uniprot.org/citations/24130829 | http://purl.uniprot.org/core/author | "Houliston S."xsd:string |
| http://purl.uniprot.org/citations/24130829 | http://purl.uniprot.org/core/author | "Houliston S."xsd:string |
| http://purl.uniprot.org/citations/24130829 | http://purl.uniprot.org/core/author | "Dombrovski L."xsd:string |
| http://purl.uniprot.org/citations/24130829 | http://purl.uniprot.org/core/author | "Dombrovski L."xsd:string |
| http://purl.uniprot.org/citations/24130829 | http://purl.uniprot.org/core/author | "Lemak A."xsd:string |
| http://purl.uniprot.org/citations/24130829 | http://purl.uniprot.org/core/author | "Lemak A."xsd:string |
| http://purl.uniprot.org/citations/24130829 | http://purl.uniprot.org/core/author | "Yap D."xsd:string |
| http://purl.uniprot.org/citations/24130829 | http://purl.uniprot.org/core/author | "Yap D."xsd:string |
| http://purl.uniprot.org/citations/24130829 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24130829 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |