| http://purl.uniprot.org/citations/24217640 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24217640 | http://www.w3.org/2000/01/rdf-schema#comment | "Long-term depression (LTD) underlies learning and memory in various brain regions. Although postsynaptic AMPA receptor trafficking mediates LTD, its underlying molecular mechanisms remain largely unclear. Here we show that stargazin, a transmembrane AMPA receptor regulatory protein, forms a ternary complex with adaptor proteins AP-2 and AP-3A in hippocampal neurons, depending on its phosphorylation state. Inhibiting the stargazin-AP-2 interaction disrupts NMDA-induced AMPA receptor endocytosis, and inhibiting that of stargazin-AP-3A abrogates the late endosomal/lysosomal trafficking of AMPA receptors, thereby upregulating receptor recycling to the cell surface. Similarly, stargazin's interaction with AP-2 or AP-3A is necessary for low-frequency stimulus-evoked LTD in CA1 hippocampal neurons. Thus, stargazin has a crucial role in NMDA-dependent LTD by regulating two trafficking pathways of AMPA receptors--transport from the cell surface to early endosomes and from early endosomes to late endosomes/lysosomes--through its sequential binding to AP-2 and AP-3A."xsd:string |
| http://purl.uniprot.org/citations/24217640 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms3759"xsd:string |
| http://purl.uniprot.org/citations/24217640 | http://purl.uniprot.org/core/author | "Matsuda S."xsd:string |
| http://purl.uniprot.org/citations/24217640 | http://purl.uniprot.org/core/author | "Nomura T."xsd:string |
| http://purl.uniprot.org/citations/24217640 | http://purl.uniprot.org/core/author | "Kohda K."xsd:string |
| http://purl.uniprot.org/citations/24217640 | http://purl.uniprot.org/core/author | "Kakegawa W."xsd:string |
| http://purl.uniprot.org/citations/24217640 | http://purl.uniprot.org/core/author | "Yuzaki M."xsd:string |
| http://purl.uniprot.org/citations/24217640 | http://purl.uniprot.org/core/author | "Budisantoso T."xsd:string |
| http://purl.uniprot.org/citations/24217640 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24217640 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/24217640 | http://purl.uniprot.org/core/pages | "2759"xsd:string |
| http://purl.uniprot.org/citations/24217640 | http://purl.uniprot.org/core/title | "Stargazin regulates AMPA receptor trafficking through adaptor protein complexes during long-term depression."xsd:string |
| http://purl.uniprot.org/citations/24217640 | http://purl.uniprot.org/core/volume | "4"xsd:string |
| http://purl.uniprot.org/citations/24217640 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24217640 |
| http://purl.uniprot.org/citations/24217640 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24217640 |
| http://purl.uniprot.org/uniprot/Q9DBG3#attribution-8746D42AB6043A7AD9099255F0D30DA6 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24217640 |
| http://purl.uniprot.org/uniprot/Q9DBG3#attribution-E7E693C5E33204E3E9623FF5C0D58468 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24217640 |
| http://purl.uniprot.org/uniprot/P84091#attribution-8746D42AB6043A7AD9099255F0D30DA6 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24217640 |
| http://purl.uniprot.org/uniprot/O54774#attribution-8746D42AB6043A7AD9099255F0D30DA6 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24217640 |
| http://purl.uniprot.org/uniprot/O88602#attribution-E7E693C5E33204E3E9623FF5C0D58468 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24217640 |
| http://purl.uniprot.org/uniprot/#_A0A338P798-mappedCitation-24217640 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24217640 |
| http://purl.uniprot.org/uniprot/#_A0A1W2P7Z2-mappedCitation-24217640 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24217640 |
| http://purl.uniprot.org/uniprot/#_A0A338P6T4-mappedCitation-24217640 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24217640 |
| http://purl.uniprot.org/uniprot/#_A0A1W2P6Q6-mappedCitation-24217640 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24217640 |