| http://purl.uniprot.org/citations/24338362 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24338362 | http://www.w3.org/2000/01/rdf-schema#comment | "The kinesin motors are important in the regulation of cellular functions such as protein trafficking, spindle organization and centrosome separation. In this study, we have identified POPX2, a serine-threonine phosphatase, as an interacting partner of the KAP3 subunit of the kinesin-2 motor. The kinesin-2 motor is a heterotrimeric complex composed of KIF3A, KIF3B motor subunits and KAP3, the non-motor subunit, which binds the cargo. Here we report that the phosphatase POPX2 is a negative regulator of the trafficking of N-cadherin and other cargoes; consequently, it markedly influences cell-cell adhesion. POPX2 affects trafficking by determining the phosphorylation status of KIF3A at serine 690. This is consistent with the observation that the KIF3A-S690A mutant is defective in cargo trafficking. Our studies also implicate CaMKII as the kinase that phosphorylates KIF3A at serine 690. These results strongly suggest that POPX2 and CaMKII are a phosphatase-kinase pair that regulates kinesin-mediated transport and cell-cell adhesion."xsd:string |
| http://purl.uniprot.org/citations/24338362 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.126482"xsd:string |
| http://purl.uniprot.org/citations/24338362 | http://purl.uniprot.org/core/author | "Zeng Y."xsd:string |
| http://purl.uniprot.org/citations/24338362 | http://purl.uniprot.org/core/author | "Li H.Y."xsd:string |
| http://purl.uniprot.org/citations/24338362 | http://purl.uniprot.org/core/author | "Lai S.K."xsd:string |
| http://purl.uniprot.org/citations/24338362 | http://purl.uniprot.org/core/author | "Koh C.G."xsd:string |
| http://purl.uniprot.org/citations/24338362 | http://purl.uniprot.org/core/author | "Phang H.Q."xsd:string |
| http://purl.uniprot.org/citations/24338362 | http://purl.uniprot.org/core/author | "Chiam K.H."xsd:string |
| http://purl.uniprot.org/citations/24338362 | http://purl.uniprot.org/core/author | "Hoon J.L."xsd:string |
| http://purl.uniprot.org/citations/24338362 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24338362 | http://purl.uniprot.org/core/name | "J Cell Sci"xsd:string |
| http://purl.uniprot.org/citations/24338362 | http://purl.uniprot.org/core/pages | "727-739"xsd:string |
| http://purl.uniprot.org/citations/24338362 | http://purl.uniprot.org/core/title | "POPX2 phosphatase regulates the KIF3 kinesin motor complex."xsd:string |
| http://purl.uniprot.org/citations/24338362 | http://purl.uniprot.org/core/volume | "127"xsd:string |
| http://purl.uniprot.org/citations/24338362 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24338362 |
| http://purl.uniprot.org/citations/24338362 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24338362 |
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