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A new T-cell receptor gene located within the alpha locus and expressed early in T-cell differentiation.

Chien Y.H., Iwashima M., Kaplan K.B., Elliott J.F., Davis M.M.

A new T-cell receptor gene lies just 5' to the J alpha C alpha coding regions. Its placement in this location suggests a novel mechanism for the regulation of expression of one T-cell receptor polypeptide to another during ontogeny. Rearrangement of this locus occurs very early in thymic differentiation and its RNA expression parallels that of the gamma-chain in thymic subpopulations, making this a possible candidate for the recently described delta-chain of the T-cell receptor.

Nature 327:677-682(1987) [PubMed] [Europe PMC]

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