| http://purl.uniprot.org/citations/24440982 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24440982 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24440982 | http://www.w3.org/2000/01/rdf-schema#comment | "Many biological processes involve gene-expression regulation by alternative splicing. Here, we identify the splicing factor SRSF6 as a regulator of wound healing and tissue homeostasis in skin. We show that SRSF6 is a proto-oncogene frequently overexpressed in human skin cancer. Overexpressing it in transgenic mice induces hyperplasia of sensitized skin and promotes aberrant alternative splicing. We identify 139 SRSF6-target genes in skin and show that this SR-rich protein binds to alternative exons in the pre-mRNA of the extracellular-matrix protein tenascin C, thus promoting the expression of isoforms characteristic of invasive and metastatic cancer independently of cell type. SRSF6 overexpression additionally results in depletion of LGR6+ stem cells and excessive keratinocyte proliferation and response to injury. Furthermore, the effects of SRSF6 in wound healing assayed in vitro depend on the tenascin-C isoforms. Thus, abnormal SR-protein expression can perturb tissue homeostasis."xsd:string |
| http://purl.uniprot.org/citations/24440982 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb.2756"xsd:string |
| http://purl.uniprot.org/citations/24440982 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb.2756"xsd:string |
| http://purl.uniprot.org/citations/24440982 | http://purl.uniprot.org/core/author | "Wilkinson J.E."xsd:string |
| http://purl.uniprot.org/citations/24440982 | http://purl.uniprot.org/core/author | "Wilkinson J.E."xsd:string |
| http://purl.uniprot.org/citations/24440982 | http://purl.uniprot.org/core/author | "Krainer A.R."xsd:string |
| http://purl.uniprot.org/citations/24440982 | http://purl.uniprot.org/core/author | "Krainer A.R."xsd:string |
| http://purl.uniprot.org/citations/24440982 | http://purl.uniprot.org/core/author | "Jensen M.A."xsd:string |
| http://purl.uniprot.org/citations/24440982 | http://purl.uniprot.org/core/author | "Jensen M.A."xsd:string |
| http://purl.uniprot.org/citations/24440982 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24440982 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24440982 | http://purl.uniprot.org/core/name | "Nat. Struct. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/24440982 | http://purl.uniprot.org/core/name | "Nat. Struct. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/24440982 | http://purl.uniprot.org/core/pages | "189-197"xsd:string |
| http://purl.uniprot.org/citations/24440982 | http://purl.uniprot.org/core/pages | "189-197"xsd:string |
| http://purl.uniprot.org/citations/24440982 | http://purl.uniprot.org/core/title | "Splicing factor SRSF6 promotes hyperplasia of sensitized skin."xsd:string |
| http://purl.uniprot.org/citations/24440982 | http://purl.uniprot.org/core/title | "Splicing factor SRSF6 promotes hyperplasia of sensitized skin."xsd:string |
| http://purl.uniprot.org/citations/24440982 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/24440982 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/24440982 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24440982 |
| http://purl.uniprot.org/citations/24440982 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24440982 |
| http://purl.uniprot.org/citations/24440982 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24440982 |
| http://purl.uniprot.org/citations/24440982 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24440982 |