| http://purl.uniprot.org/citations/24514953 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24514953 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24514953 | http://www.w3.org/2000/01/rdf-schema#comment | "Secretoglobin (SCGB) 3A2 was originally identified as a downstream target for the homeodomain transcription factor NKX2-1 in the lung. NKX2-1 plays a role in the genesis and expression of genes in the thyroid, lung and ventral forebrain; Nkx2-1-null mice have no thyroid and pituitary and severely hypoplastic lungs and hypothalamus. To demonstrate whether SCGB3A2 plays any role in pituitary hormone production, NKX2-1 and SCGB3A2 expression in the mouse pituitary gland was examined by immunohistochemical analysis and RT-PCR. NKX2-1 was localized in the posterior pituitary lobe, whereas SCGB3A2 was observed in both anterior and posterior lobes as shown by immunohistochemistry and RT-PCR. Expression of CCAAT-enhancer binding proteins (C/EBPs), which regulate mouse Scgb3a2 transcription, was also examined by RT-PCR. C/EBPβ, γ, δ and ζ were expressed in the adult mouse pituitary gland. SCGB3A2 was expressed in the anterior and posterior lobes from postnatal days 1 and 5, respectively and the areas where SCGB3A2 expression was found coincided with the area where FSH-secreting cells were found. Double-staining for SCGB3A2 and pituitary hormones revealed that SCGB3A2 was mainly localized in gonadotrophs in 49 % of FSH-secreting cells and 47 % of LH-secreting cells. In addition, SCGB3A2 dramatically inhibited LH and FSH mRNA expression in rat pituitary primary cell cultures. These results suggest that SCGB3A2 regulates FSH/LH production in the anterior pituitary lobe and that transcription factors other than NKX2-1 may regulate SCGB3A2 expression."xsd:string |
| http://purl.uniprot.org/citations/24514953 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00441-014-1794-z"xsd:string |
| http://purl.uniprot.org/citations/24514953 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00441-014-1794-z"xsd:string |
| http://purl.uniprot.org/citations/24514953 | http://purl.uniprot.org/core/author | "Abe H."xsd:string |
| http://purl.uniprot.org/citations/24514953 | http://purl.uniprot.org/core/author | "Abe H."xsd:string |
| http://purl.uniprot.org/citations/24514953 | http://purl.uniprot.org/core/author | "Kimura S."xsd:string |
| http://purl.uniprot.org/citations/24514953 | http://purl.uniprot.org/core/author | "Kimura S."xsd:string |
| http://purl.uniprot.org/citations/24514953 | http://purl.uniprot.org/core/author | "Sakai T."xsd:string |
| http://purl.uniprot.org/citations/24514953 | http://purl.uniprot.org/core/author | "Sakai T."xsd:string |
| http://purl.uniprot.org/citations/24514953 | http://purl.uniprot.org/core/author | "Tahara S."xsd:string |
| http://purl.uniprot.org/citations/24514953 | http://purl.uniprot.org/core/author | "Tahara S."xsd:string |
| http://purl.uniprot.org/citations/24514953 | http://purl.uniprot.org/core/author | "Kurotani R."xsd:string |
| http://purl.uniprot.org/citations/24514953 | http://purl.uniprot.org/core/author | "Kurotani R."xsd:string |
| http://purl.uniprot.org/citations/24514953 | http://purl.uniprot.org/core/author | "Sakata I."xsd:string |
| http://purl.uniprot.org/citations/24514953 | http://purl.uniprot.org/core/author | "Sakata I."xsd:string |
| http://purl.uniprot.org/citations/24514953 | http://purl.uniprot.org/core/author | "Miyano Y."xsd:string |
| http://purl.uniprot.org/citations/24514953 | http://purl.uniprot.org/core/author | "Miyano Y."xsd:string |
| http://purl.uniprot.org/citations/24514953 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24514953 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24514953 | http://purl.uniprot.org/core/name | "Cell Tissue Res."xsd:string |
| http://purl.uniprot.org/citations/24514953 | http://purl.uniprot.org/core/name | "Cell Tissue Res."xsd:string |
| http://purl.uniprot.org/citations/24514953 | http://purl.uniprot.org/core/pages | "253-260"xsd:string |
| http://purl.uniprot.org/citations/24514953 | http://purl.uniprot.org/core/pages | "253-260"xsd:string |