| http://purl.uniprot.org/citations/24554767 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24554767 | http://www.w3.org/2000/01/rdf-schema#comment | "The yeast C-type cyclin represses the transcription of genes required for the stress response and meiosis. To relieve this repression, cyclin C undergoes nuclear-to-cytoplasmic translocation in response to many stressors, including hydrogen peroxide, where it is destroyed by ubiquitin-mediated proteolysis. Before its destruction, cyclin C promotes stress-induced mitochondrial fission and programmed cell death, indicating that relocalization is an important cell fate regulator. Here we show that cyclin C cytoplasmic translocation requires the cell wall integrity (CWI) mitogen-activated protein kinase Slt2p, its pseudokinase paralogue, Kdx1p, and an associating transcription factor, Ask10p. Furthermore, Slt2p and Kdx1p regulate cyclin C stability through different but required mechanisms. Slt2p associates with, and directly phosphorylates, cyclin C at Ser-266. Eliminating or mimicking phosphorylation at this site restricts or enhances cyclin C cytoplasmic translocation and degradation, respectively. Conversely, Kdx1p does not bind cyclin C but instead coimmunoprecipitates with Ask10p, a transcription factor previously identified as a regulator of cyclin C destruction. These results reveal a complex regulatory circuitry involving both downstream effectors of the CWI mitogen-activated protein kinase signal transduction pathway to target the relocalization and consequent destruction of a single transcriptional repressor."xsd:string |
| http://purl.uniprot.org/citations/24554767 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e13-09-0550"xsd:string |
| http://purl.uniprot.org/citations/24554767 | http://purl.uniprot.org/core/author | "Jin C."xsd:string |
| http://purl.uniprot.org/citations/24554767 | http://purl.uniprot.org/core/author | "Cooper K.F."xsd:string |
| http://purl.uniprot.org/citations/24554767 | http://purl.uniprot.org/core/author | "Strich R."xsd:string |
| http://purl.uniprot.org/citations/24554767 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24554767 | http://purl.uniprot.org/core/name | "Mol Biol Cell"xsd:string |
| http://purl.uniprot.org/citations/24554767 | http://purl.uniprot.org/core/pages | "1396-1407"xsd:string |
| http://purl.uniprot.org/citations/24554767 | http://purl.uniprot.org/core/title | "Slt2p phosphorylation induces cyclin C nuclear-to-cytoplasmic translocation in response to oxidative stress."xsd:string |
| http://purl.uniprot.org/citations/24554767 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/24554767 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24554767 |
| http://purl.uniprot.org/citations/24554767 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24554767 |
| http://purl.uniprot.org/uniprot/Q00772#attribution-D3BA3E2EF3342D1D32BCE40AF46C37DD | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24554767 |
| http://purl.uniprot.org/uniprot/#_P39073-mappedCitation-24554767 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24554767 |
| http://purl.uniprot.org/uniprot/#_P48361-mappedCitation-24554767 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24554767 |
| http://purl.uniprot.org/uniprot/#_Q00772-mappedCitation-24554767 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24554767 |
| http://purl.uniprot.org/uniprot/#_P36005-mappedCitation-24554767 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24554767 |
| http://purl.uniprot.org/uniprot/#_P47821-mappedCitation-24554767 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24554767 |
| http://purl.uniprot.org/uniprot/P47821 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24554767 |
| http://purl.uniprot.org/uniprot/P39073 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24554767 |
| http://purl.uniprot.org/uniprot/Q00772 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24554767 |
| http://purl.uniprot.org/uniprot/P48361 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24554767 |
| http://purl.uniprot.org/uniprot/P36005 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24554767 |