| http://purl.uniprot.org/citations/24639097 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24639097 | http://www.w3.org/2000/01/rdf-schema#comment | "The placenta is thought to have a critical role in the pathogenesis of gestational diabetes mellitus (GDM), as GDM‑associated complications resolve following delivery. Placenta-specific microRNAs (miRNAs) may contribute to the pathology of the development of GDM. The aim of the present study was to evaluate whether the placenta-specific miR-518d contributes to the development of GDM. It was revealed that miR-518d expression was higher in placentas taken from patients with GDM compared with control placentas, whereas the protein levels of the predicted miR-518d target gene, peroxisome proliferator-activated receptor-α (PPARα), were lower in placentas from patients with GDM compared with those from control subjects. It was also demonstrated that PPARα was a direct target of miR-518d with a specific binding site at the seed sequence, which determines target specificity. In the placentas of females with GDM increased levels of miR-518d were negatively correlated with the levels of PPARα protein. As PPARα dysregulation may be related to the development of GDM, it is suggested that upregulation of miR-518d may be associated with the pathogenesis of GDM via an effect on the regulation of PPARα expression."xsd:string |
| http://purl.uniprot.org/citations/24639097 | http://purl.org/dc/terms/identifier | "doi:10.3892/mmr.2014.2058"xsd:string |
| http://purl.uniprot.org/citations/24639097 | http://purl.uniprot.org/core/author | "Shi Z."xsd:string |
| http://purl.uniprot.org/citations/24639097 | http://purl.uniprot.org/core/author | "Zhang T."xsd:string |
| http://purl.uniprot.org/citations/24639097 | http://purl.uniprot.org/core/author | "Zhao C."xsd:string |
| http://purl.uniprot.org/citations/24639097 | http://purl.uniprot.org/core/author | "Ding H."xsd:string |
| http://purl.uniprot.org/citations/24639097 | http://purl.uniprot.org/core/author | "Ling X."xsd:string |
| http://purl.uniprot.org/citations/24639097 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24639097 | http://purl.uniprot.org/core/name | "Mol Med Rep"xsd:string |
| http://purl.uniprot.org/citations/24639097 | http://purl.uniprot.org/core/pages | "2085-2090"xsd:string |
| http://purl.uniprot.org/citations/24639097 | http://purl.uniprot.org/core/title | "MicroRNA-518d regulates PPARalpha protein expression in the placentas of females with gestational diabetes mellitus."xsd:string |
| http://purl.uniprot.org/citations/24639097 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/24639097 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24639097 |
| http://purl.uniprot.org/citations/24639097 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24639097 |
| http://purl.uniprot.org/uniprot/Q07869#attribution-2A21EE068E5DC0A8B06E05C891BA90EE | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24639097 |