| http://purl.uniprot.org/citations/24700158 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24700158 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24700158 | http://www.w3.org/2000/01/rdf-schema#comment | "The nuclear lamina is an extensive protein network that contributes to nuclear structure and function. LEM domain (LAP2, emerin, MAN1 domain, LEM-D) proteins are components of the nuclear lamina, identified by a shared ∼45-amino-acid motif that binds Barrier-to-autointegration factor (BAF), a chromatin-interacting protein. Drosophila melanogaster has three nuclear lamina LEM-D proteins, named Otefin (Ote), Bocksbeutel (Bocks), and dMAN1. Although these LEM-D proteins are globally expressed, loss of either Ote or dMAN1 causes tissue-specific defects in adult flies that differ from each other. The reason for such distinct tissue-restricted defects is unknown. Here, we generated null alleles of bocks, finding that loss of Bocks causes no overt adult phenotypes. Next, we defined phenotypes associated with lem-d double mutants. Although the absence of individual LEM-D proteins does not affect viability, loss of any two proteins causes lethality. Mutant phenotypes displayed by lem-d double mutants differ from baf mutants, suggesting that BAF function is retained in animals with a single nuclear lamina LEM-D protein. Interestingly, lem-d double mutants displayed distinct developmental and cellular mutant phenotypes, suggesting that Drosophila LEM-D proteins have developmental functions that are differentially shared with other LEM-D family members. This conclusion is supported by studies showing that ectopically produced LEM-D proteins have distinct capacities to rescue the tissue-specific phenotypes found in single lem-d mutants. Our findings predict that cell-specific mutant phenotypes caused by loss of LEM-D proteins reflect both the constellation of LEM-D proteins within the nuclear lamina and the capacity of functional compensation of the remaining LEM-D proteins."xsd:string |
| http://purl.uniprot.org/citations/24700158 | http://purl.org/dc/terms/identifier | "doi:10.1534/genetics.114.162941"xsd:string |
| http://purl.uniprot.org/citations/24700158 | http://purl.org/dc/terms/identifier | "doi:10.1534/genetics.114.162941"xsd:string |
| http://purl.uniprot.org/citations/24700158 | http://purl.uniprot.org/core/author | "Barton L.J."xsd:string |
| http://purl.uniprot.org/citations/24700158 | http://purl.uniprot.org/core/author | "Barton L.J."xsd:string |
| http://purl.uniprot.org/citations/24700158 | http://purl.uniprot.org/core/author | "Geyer P.K."xsd:string |
| http://purl.uniprot.org/citations/24700158 | http://purl.uniprot.org/core/author | "Geyer P.K."xsd:string |
| http://purl.uniprot.org/citations/24700158 | http://purl.uniprot.org/core/author | "Lovander K.E."xsd:string |
| http://purl.uniprot.org/citations/24700158 | http://purl.uniprot.org/core/author | "Lovander K.E."xsd:string |
| http://purl.uniprot.org/citations/24700158 | http://purl.uniprot.org/core/author | "Martin M.J."xsd:string |
| http://purl.uniprot.org/citations/24700158 | http://purl.uniprot.org/core/author | "Martin M.J."xsd:string |
| http://purl.uniprot.org/citations/24700158 | http://purl.uniprot.org/core/author | "Pinto B.S."xsd:string |
| http://purl.uniprot.org/citations/24700158 | http://purl.uniprot.org/core/author | "Pinto B.S."xsd:string |
| http://purl.uniprot.org/citations/24700158 | http://purl.uniprot.org/core/author | "Skopec H.M."xsd:string |
| http://purl.uniprot.org/citations/24700158 | http://purl.uniprot.org/core/author | "Skopec H.M."xsd:string |
| http://purl.uniprot.org/citations/24700158 | http://purl.uniprot.org/core/author | "Wilmington S.R."xsd:string |
| http://purl.uniprot.org/citations/24700158 | http://purl.uniprot.org/core/author | "Wilmington S.R."xsd:string |
| http://purl.uniprot.org/citations/24700158 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24700158 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24700158 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
| http://purl.uniprot.org/citations/24700158 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
| http://purl.uniprot.org/citations/24700158 | http://purl.uniprot.org/core/pages | "653-665"xsd:string |
| http://purl.uniprot.org/citations/24700158 | http://purl.uniprot.org/core/pages | "653-665"xsd:string |