| http://purl.uniprot.org/citations/24746700 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24746700 | http://www.w3.org/2000/01/rdf-schema#comment | "Mutations within BRCA1 predispose carriers to a high risk of breast and ovarian cancers. BRCA1 functions to maintain genomic stability through the assembly of multiple protein complexes involved in DNA repair, cell-cycle arrest, and transcriptional regulation. Here, we report the identification of a DNA damage-induced BRCA1 protein complex containing BCLAF1 and other key components of the mRNA-splicing machinery. In response to DNA damage, this complex regulates pre-mRNA splicing of a number of genes involved in DNA damage signaling and repair, thereby promoting the stability of these transcripts/proteins. Further, we show that abrogation of this complex results in sensitivity to DNA damage, defective DNA repair, and genomic instability. Interestingly, mutations in a number of proteins found within this complex have been identified in numerous cancer types. These data suggest that regulation of splicing by the BRCA1-mRNA splicing complex plays an important role in the cellular response to DNA damage."xsd:string |
| http://purl.uniprot.org/citations/24746700 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2014.03.021"xsd:string |
| http://purl.uniprot.org/citations/24746700 | http://purl.uniprot.org/core/author | "Richard D.J."xsd:string |
| http://purl.uniprot.org/citations/24746700 | http://purl.uniprot.org/core/author | "Powell A.J."xsd:string |
| http://purl.uniprot.org/citations/24746700 | http://purl.uniprot.org/core/author | "Lukashchuk N."xsd:string |
| http://purl.uniprot.org/citations/24746700 | http://purl.uniprot.org/core/author | "McDade S.S."xsd:string |
| http://purl.uniprot.org/citations/24746700 | http://purl.uniprot.org/core/author | "Boultwood J."xsd:string |
| http://purl.uniprot.org/citations/24746700 | http://purl.uniprot.org/core/author | "Pellagatti A."xsd:string |
| http://purl.uniprot.org/citations/24746700 | http://purl.uniprot.org/core/author | "McCance D.J."xsd:string |
| http://purl.uniprot.org/citations/24746700 | http://purl.uniprot.org/core/author | "Gorski J.J."xsd:string |
| http://purl.uniprot.org/citations/24746700 | http://purl.uniprot.org/core/author | "Harkin D.P."xsd:string |
| http://purl.uniprot.org/citations/24746700 | http://purl.uniprot.org/core/author | "Savage K.I."xsd:string |
| http://purl.uniprot.org/citations/24746700 | http://purl.uniprot.org/core/author | "Salto-Tellez M."xsd:string |
| http://purl.uniprot.org/citations/24746700 | http://purl.uniprot.org/core/author | "Barros E.M."xsd:string |
| http://purl.uniprot.org/citations/24746700 | http://purl.uniprot.org/core/author | "McCluggage W.G."xsd:string |
| http://purl.uniprot.org/citations/24746700 | http://purl.uniprot.org/core/author | "Irwin G.W."xsd:string |
| http://purl.uniprot.org/citations/24746700 | http://purl.uniprot.org/core/author | "Manti L."xsd:string |
| http://purl.uniprot.org/citations/24746700 | http://purl.uniprot.org/core/author | "Schettino G."xsd:string |
| http://purl.uniprot.org/citations/24746700 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24746700 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/24746700 | http://purl.uniprot.org/core/pages | "445-459"xsd:string |
| http://purl.uniprot.org/citations/24746700 | http://purl.uniprot.org/core/title | "Identification of a BRCA1-mRNA splicing complex required for efficient DNA repair and maintenance of genomic stability."xsd:string |
| http://purl.uniprot.org/citations/24746700 | http://purl.uniprot.org/core/volume | "54"xsd:string |
| http://purl.uniprot.org/citations/24746700 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24746700 |