| http://purl.uniprot.org/citations/24753571 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24753571 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24753571 | http://www.w3.org/2000/01/rdf-schema#comment | "The human RNA-editing enzyme adenosine deaminase acting on RNA (ADAR1) carries a unique nuclear localization signal (NLS) that overlaps one of its double-stranded RNA-binding domains (dsRBDs). This dsRBD-NLS is recognized by the nuclear import receptor transportin 1 (Trn1; also called karyopherin-β2) in an RNA-sensitive manner. Most Trn1 cargos bear a well-characterized proline-tyrosine-NLS, which is missing from the dsRBD-NLS. Here, we report the structure of the dsRBD-NLS, which reveals an unusual dsRBD fold extended by an additional N-terminal α-helix that brings the N- and C-terminal flanking regions in close proximity. We demonstrate experimentally that the atypical ADAR1-NLS is bimodular and is formed by the combination of the two flexible fragments flanking the folded domain. The intervening dsRBD acts only as an RNA-sensing scaffold, allowing the two NLS modules to be properly positioned for interacting with Trn1. We also provide a structural model showing how Trn1 can recognize the dsRBD-NLS and how dsRNA binding can interfere with Trn1 binding."xsd:string |
| http://purl.uniprot.org/citations/24753571 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1323698111"xsd:string |
| http://purl.uniprot.org/citations/24753571 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1323698111"xsd:string |
| http://purl.uniprot.org/citations/24753571 | http://purl.uniprot.org/core/author | "Banerjee S."xsd:string |
| http://purl.uniprot.org/citations/24753571 | http://purl.uniprot.org/core/author | "Banerjee S."xsd:string |
| http://purl.uniprot.org/citations/24753571 | http://purl.uniprot.org/core/author | "Allain F.H."xsd:string |
| http://purl.uniprot.org/citations/24753571 | http://purl.uniprot.org/core/author | "Allain F.H."xsd:string |
| http://purl.uniprot.org/citations/24753571 | http://purl.uniprot.org/core/author | "Barraud P."xsd:string |
| http://purl.uniprot.org/citations/24753571 | http://purl.uniprot.org/core/author | "Barraud P."xsd:string |
| http://purl.uniprot.org/citations/24753571 | http://purl.uniprot.org/core/author | "Jantsch M.F."xsd:string |
| http://purl.uniprot.org/citations/24753571 | http://purl.uniprot.org/core/author | "Jantsch M.F."xsd:string |
| http://purl.uniprot.org/citations/24753571 | http://purl.uniprot.org/core/author | "Mohamed W.I."xsd:string |
| http://purl.uniprot.org/citations/24753571 | http://purl.uniprot.org/core/author | "Mohamed W.I."xsd:string |
| http://purl.uniprot.org/citations/24753571 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24753571 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24753571 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/24753571 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/24753571 | http://purl.uniprot.org/core/pages | "E1852-E1861"xsd:string |
| http://purl.uniprot.org/citations/24753571 | http://purl.uniprot.org/core/pages | "E1852-E1861"xsd:string |
| http://purl.uniprot.org/citations/24753571 | http://purl.uniprot.org/core/title | "A bimodular nuclear localization signal assembled via an extended double-stranded RNA-binding domain acts as an RNA-sensing signal for transportin 1."xsd:string |
| http://purl.uniprot.org/citations/24753571 | http://purl.uniprot.org/core/title | "A bimodular nuclear localization signal assembled via an extended double-stranded RNA-binding domain acts as an RNA-sensing signal for transportin 1."xsd:string |
| http://purl.uniprot.org/citations/24753571 | http://purl.uniprot.org/core/volume | "111"xsd:string |
| http://purl.uniprot.org/citations/24753571 | http://purl.uniprot.org/core/volume | "111"xsd:string |