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http://purl.uniprot.org/citations/24813629http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/24813629http://www.w3.org/2000/01/rdf-schema#comment"As a cleavage enzyme of precursor TNF-α, the high expression level of ADAM17 in endothelial cells is an important factor in atherosclerosis. In this study, we demonstrate that ADAM17 is the target of miR-152. We found that miR-152 could reduce TNF precursor cleavage and inhibit cell proliferation and migration by targeting ADAM17 in human umbilical vein endothelial cells (HUVECs). Furthermore, the expression pattern of miR-152 and corresponding target ADAM17 was opposite in HUVECs under hypoxic conditions. The levels of circulating miR-152 in AS patient sera were lower than those detected in the sera of normal individuals. Our results indicate that miR-152 may be involved in the development of human atherosclerosis and could be used as diagnostic biomarker or therapeutic target in atherosclerosis."xsd:string
http://purl.uniprot.org/citations/24813629http://purl.org/dc/terms/identifier"doi:10.1016/j.febslet.2014.04.037"xsd:string
http://purl.uniprot.org/citations/24813629http://purl.uniprot.org/core/author"Gao C."xsd:string
http://purl.uniprot.org/citations/24813629http://purl.uniprot.org/core/author"Hou L."xsd:string
http://purl.uniprot.org/citations/24813629http://purl.uniprot.org/core/author"Ge X."xsd:string
http://purl.uniprot.org/citations/24813629http://purl.uniprot.org/core/author"Li H."xsd:string
http://purl.uniprot.org/citations/24813629http://purl.uniprot.org/core/author"Li J."xsd:string
http://purl.uniprot.org/citations/24813629http://purl.uniprot.org/core/author"Li T."xsd:string
http://purl.uniprot.org/citations/24813629http://purl.uniprot.org/core/author"Huang A."xsd:string
http://purl.uniprot.org/citations/24813629http://purl.uniprot.org/core/author"Qin X."xsd:string
http://purl.uniprot.org/citations/24813629http://purl.uniprot.org/core/author"Wu Y."xsd:string
http://purl.uniprot.org/citations/24813629http://purl.uniprot.org/core/author"Zhao Q."xsd:string
http://purl.uniprot.org/citations/24813629http://purl.uniprot.org/core/author"Wang R."xsd:string
http://purl.uniprot.org/citations/24813629http://purl.uniprot.org/core/author"Su X."xsd:string
http://purl.uniprot.org/citations/24813629http://purl.uniprot.org/core/author"Ding H."xsd:string
http://purl.uniprot.org/citations/24813629http://purl.uniprot.org/core/author"Fang T."xsd:string
http://purl.uniprot.org/citations/24813629http://purl.uniprot.org/core/author"Shao N."xsd:string
http://purl.uniprot.org/citations/24813629http://purl.uniprot.org/core/date"2014"xsd:gYear
http://purl.uniprot.org/citations/24813629http://purl.uniprot.org/core/name"FEBS Lett"xsd:string
http://purl.uniprot.org/citations/24813629http://purl.uniprot.org/core/pages"2063-2069"xsd:string
http://purl.uniprot.org/citations/24813629http://purl.uniprot.org/core/title"MiR-152 reduces human umbilical vein endothelial cell proliferation and migration by targeting ADAM17."xsd:string
http://purl.uniprot.org/citations/24813629http://purl.uniprot.org/core/volume"588"xsd:string
http://purl.uniprot.org/citations/24813629http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/24813629
http://purl.uniprot.org/citations/24813629http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/24813629