| http://purl.uniprot.org/citations/24819384 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24819384 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24819384 | http://www.w3.org/2000/01/rdf-schema#comment | "Endosomal protein sorting controls the localization of many physiologically important proteins and is linked to several neurodegenerative diseases. VPS35 is a component of the retromer complex, which mediates endosome-to-Golgi retrieval of membrane proteins such as the cation-independent mannose 6-phosphate receptor. Furthermore, retromer is also required for the endosomal recruitment of the actin nucleation promoting WASH complex. The VPS35 D620N mutation causes a rare form of autosomal-dominant Parkinson's disease (PD). Here we show that this mutant associates poorly with the WASH complex and impairs WASH recruitment to endosomes. Autophagy is impaired in cells expressing PD-mutant VPS35 or lacking WASH. The autophagy defects can be explained, at least in part, by abnormal trafficking of the autophagy protein ATG9A. Thus, the PD-causing D620N mutation in VPS35 restricts WASH complex recruitment to endosomes, and reveals a novel role for the WASH complex in autophagosome formation."xsd:string |
| http://purl.uniprot.org/citations/24819384 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms4828"xsd:string |
| http://purl.uniprot.org/citations/24819384 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms4828"xsd:string |
| http://purl.uniprot.org/citations/24819384 | http://purl.uniprot.org/core/author | "Harbour M.E."xsd:string |
| http://purl.uniprot.org/citations/24819384 | http://purl.uniprot.org/core/author | "Harbour M.E."xsd:string |
| http://purl.uniprot.org/citations/24819384 | http://purl.uniprot.org/core/author | "Moreau K."xsd:string |
| http://purl.uniprot.org/citations/24819384 | http://purl.uniprot.org/core/author | "Moreau K."xsd:string |
| http://purl.uniprot.org/citations/24819384 | http://purl.uniprot.org/core/author | "Rubinsztein D.C."xsd:string |
| http://purl.uniprot.org/citations/24819384 | http://purl.uniprot.org/core/author | "Rubinsztein D.C."xsd:string |
| http://purl.uniprot.org/citations/24819384 | http://purl.uniprot.org/core/author | "Seaman M.N."xsd:string |
| http://purl.uniprot.org/citations/24819384 | http://purl.uniprot.org/core/author | "Seaman M.N."xsd:string |
| http://purl.uniprot.org/citations/24819384 | http://purl.uniprot.org/core/author | "Jimenez-Sanchez M."xsd:string |
| http://purl.uniprot.org/citations/24819384 | http://purl.uniprot.org/core/author | "Jimenez-Sanchez M."xsd:string |
| http://purl.uniprot.org/citations/24819384 | http://purl.uniprot.org/core/author | "Zavodszky E."xsd:string |
| http://purl.uniprot.org/citations/24819384 | http://purl.uniprot.org/core/author | "Zavodszky E."xsd:string |
| http://purl.uniprot.org/citations/24819384 | http://purl.uniprot.org/core/author | "Breusegem S.Y."xsd:string |
| http://purl.uniprot.org/citations/24819384 | http://purl.uniprot.org/core/author | "Breusegem S.Y."xsd:string |
| http://purl.uniprot.org/citations/24819384 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24819384 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24819384 | http://purl.uniprot.org/core/name | "Nat. Commun."xsd:string |
| http://purl.uniprot.org/citations/24819384 | http://purl.uniprot.org/core/name | "Nat. Commun."xsd:string |
| http://purl.uniprot.org/citations/24819384 | http://purl.uniprot.org/core/pages | "3828"xsd:string |
| http://purl.uniprot.org/citations/24819384 | http://purl.uniprot.org/core/pages | "3828"xsd:string |