| http://purl.uniprot.org/citations/24899725 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24899725 | http://www.w3.org/2000/01/rdf-schema#comment | "DJ-1 (PARK7) is a gene linked to autosomal recessive Parkinson disease (PD). We showed previously that DJ-1 loss sensitizes neurons in models of PD and stroke. However, the biochemical mechanisms underlying this protective role are not completely clear. Here, we identify Von Hippel Lindau (VHL) protein as a critical DJ-1-interacting protein. We provide evidence that DJ-1 negatively regulates VHL ubiquitination activity of the α-subunit of hypoxia-inducible factor-1 (HIF-1α) by inhibiting HIF-VHL interaction. Consistent with this observation, DJ-1 deficiency leads to lowered HIF-1α levels in models of both hypoxia and oxidative stress, two stresses known to stabilize HIF-1α. We also demonstrate that HIF-1α accumulation rescues DJ-1-deficient neurons against 1-methyl-4-phenylpyridinium-induced toxicity. Interestingly, lymphoblast cells extracted from DJ-1-related PD patients show impaired HIF-1α stabilization when compared with normal individuals, indicating that the DJ-1-VHL link may also be relevant to a human context. Together, our findings delineate a model by which DJ-1 mediates neuronal survival by regulation of the VHL-HIF-1α pathway."xsd:string |
| http://purl.uniprot.org/citations/24899725 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.1244-13.2014"xsd:string |
| http://purl.uniprot.org/citations/24899725 | http://purl.uniprot.org/core/author | "Lee S."xsd:string |
| http://purl.uniprot.org/citations/24899725 | http://purl.uniprot.org/core/author | "Qu D."xsd:string |
| http://purl.uniprot.org/citations/24899725 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/24899725 | http://purl.uniprot.org/core/author | "Mak T.W."xsd:string |
| http://purl.uniprot.org/citations/24899725 | http://purl.uniprot.org/core/author | "Park D.S."xsd:string |
| http://purl.uniprot.org/citations/24899725 | http://purl.uniprot.org/core/author | "Figeys D."xsd:string |
| http://purl.uniprot.org/citations/24899725 | http://purl.uniprot.org/core/author | "Slack R.S."xsd:string |
| http://purl.uniprot.org/citations/24899725 | http://purl.uniprot.org/core/author | "Rousseaux M.W."xsd:string |
| http://purl.uniprot.org/citations/24899725 | http://purl.uniprot.org/core/author | "Callaghan S."xsd:string |
| http://purl.uniprot.org/citations/24899725 | http://purl.uniprot.org/core/author | "Aleyasin H."xsd:string |
| http://purl.uniprot.org/citations/24899725 | http://purl.uniprot.org/core/author | "Irrcher I."xsd:string |
| http://purl.uniprot.org/citations/24899725 | http://purl.uniprot.org/core/author | "Parsanejad M."xsd:string |
| http://purl.uniprot.org/citations/24899725 | http://purl.uniprot.org/core/author | "Kamkar F."xsd:string |
| http://purl.uniprot.org/citations/24899725 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24899725 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/24899725 | http://purl.uniprot.org/core/pages | "8043-8050"xsd:string |
| http://purl.uniprot.org/citations/24899725 | http://purl.uniprot.org/core/title | "Regulation of the VHL/HIF-1 pathway by DJ-1."xsd:string |
| http://purl.uniprot.org/citations/24899725 | http://purl.uniprot.org/core/volume | "34"xsd:string |
| http://purl.uniprot.org/citations/24899725 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24899725 |
| http://purl.uniprot.org/citations/24899725 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24899725 |
| http://purl.uniprot.org/uniprot/Q16665#attribution-21F77E28B9EFCD080B90B7CE671A9C2B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24899725 |
| http://purl.uniprot.org/uniprot/Q99497#attribution-21F77E28B9EFCD080B90B7CE671A9C2B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24899725 |