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http://purl.uniprot.org/citations/2501794http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/2501794http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/2501794http://www.w3.org/2000/01/rdf-schema#comment"Nine polypeptide peaks with antibiotic activity were resolved from human polymorphonuclear leukocyte azurophil granule membranes. All but 1 of the 12 constituent polypeptides were identified by N-terminal sequence analysis. Near quantitative recovery of protein and activity permitted an assessment of the contribution of each species to the overall respiratory-burst-independent antimicrobial capacity of the cell. Three uncharacterized polypeptides were discovered, including two broad-spectrum antibiotics. One of these, a defensin that we have designated human neutrophil antimicrobial peptide 4, was more potent than previously described defensins but represented less than 1% of the total protein. The other, named azurocidin, was abundant and comparable to bactericidal permeability-increasing factor in its contribution to the killing of Escherichia coli."xsd:string
http://purl.uniprot.org/citations/2501794http://purl.org/dc/terms/identifier"doi:10.1073/pnas.86.14.5610"xsd:string
http://purl.uniprot.org/citations/2501794http://purl.org/dc/terms/identifier"doi:10.1073/pnas.86.14.5610"xsd:string
http://purl.uniprot.org/citations/2501794http://purl.uniprot.org/core/author"Seeger M."xsd:string
http://purl.uniprot.org/citations/2501794http://purl.uniprot.org/core/author"Seeger M."xsd:string
http://purl.uniprot.org/citations/2501794http://purl.uniprot.org/core/author"Wilde C."xsd:string
http://purl.uniprot.org/citations/2501794http://purl.uniprot.org/core/author"Wilde C."xsd:string
http://purl.uniprot.org/citations/2501794http://purl.uniprot.org/core/author"Griffith J."xsd:string
http://purl.uniprot.org/citations/2501794http://purl.uniprot.org/core/author"Griffith J."xsd:string
http://purl.uniprot.org/citations/2501794http://purl.uniprot.org/core/author"Nathan C.F."xsd:string
http://purl.uniprot.org/citations/2501794http://purl.uniprot.org/core/author"Nathan C.F."xsd:string
http://purl.uniprot.org/citations/2501794http://purl.uniprot.org/core/author"Campanelli D."xsd:string
http://purl.uniprot.org/citations/2501794http://purl.uniprot.org/core/author"Campanelli D."xsd:string
http://purl.uniprot.org/citations/2501794http://purl.uniprot.org/core/author"Gabay J.E."xsd:string
http://purl.uniprot.org/citations/2501794http://purl.uniprot.org/core/author"Gabay J.E."xsd:string
http://purl.uniprot.org/citations/2501794http://purl.uniprot.org/core/author"Marra M.N."xsd:string
http://purl.uniprot.org/citations/2501794http://purl.uniprot.org/core/author"Marra M.N."xsd:string
http://purl.uniprot.org/citations/2501794http://purl.uniprot.org/core/author"Scott R.W."xsd:string
http://purl.uniprot.org/citations/2501794http://purl.uniprot.org/core/author"Scott R.W."xsd:string
http://purl.uniprot.org/citations/2501794http://purl.uniprot.org/core/date"1989"xsd:gYear
http://purl.uniprot.org/citations/2501794http://purl.uniprot.org/core/date"1989"xsd:gYear
http://purl.uniprot.org/citations/2501794http://purl.uniprot.org/core/name"Proc. Natl. Acad. Sci. U.S.A."xsd:string
http://purl.uniprot.org/citations/2501794http://purl.uniprot.org/core/name"Proc. Natl. Acad. Sci. U.S.A."xsd:string