| http://purl.uniprot.org/citations/25078033 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25078033 | http://www.w3.org/2000/01/rdf-schema#comment | "Squamous cell carcinoma of the head and neck (SCCHN) is a common, aggressive, treatment-resistant cancer with a high recurrence rate and mortality, but the mechanism of treatment resistance remains unclear. Here we describe a mechanism where the AAA-ATPase TRIP13 promotes treatment resistance. Overexpression of TRIP13 in non-malignant cells results in malignant transformation. High expression of TRIP13 in SCCHN leads to aggressive, treatment-resistant tumors and enhanced repair of DNA damage. Using mass spectrometry, we identify DNA-PKcs complex proteins that mediate nonhomologous end joining (NHEJ), as TRIP13-binding partners. Using repair-deficient reporter systems, we show that TRIP13 promotes NHEJ, even when homologous recombination is intact. Importantly, overexpression of TRIP13 sensitizes SCCHN to an inhibitor of DNA-PKcs. Thus, this study defines a new mechanism of treatment resistance in SCCHN and underscores the importance of targeting NHEJ to overcome treatment failure in SCCHN and potentially in other cancers that overexpress TRIP13."xsd:string |
| http://purl.uniprot.org/citations/25078033 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms5527"xsd:string |
| http://purl.uniprot.org/citations/25078033 | http://purl.uniprot.org/core/author | "Banerjee R."xsd:string |
| http://purl.uniprot.org/citations/25078033 | http://purl.uniprot.org/core/author | "Liu M."xsd:string |
| http://purl.uniprot.org/citations/25078033 | http://purl.uniprot.org/core/author | "Basrur V."xsd:string |
| http://purl.uniprot.org/citations/25078033 | http://purl.uniprot.org/core/author | "Palanisamy N."xsd:string |
| http://purl.uniprot.org/citations/25078033 | http://purl.uniprot.org/core/author | "Chinnaiyan A.M."xsd:string |
| http://purl.uniprot.org/citations/25078033 | http://purl.uniprot.org/core/author | "Mani R.S."xsd:string |
| http://purl.uniprot.org/citations/25078033 | http://purl.uniprot.org/core/author | "Russo N."xsd:string |
| http://purl.uniprot.org/citations/25078033 | http://purl.uniprot.org/core/author | "Varambally S."xsd:string |
| http://purl.uniprot.org/citations/25078033 | http://purl.uniprot.org/core/author | "Nyati M.K."xsd:string |
| http://purl.uniprot.org/citations/25078033 | http://purl.uniprot.org/core/author | "D'Silva N.J."xsd:string |
| http://purl.uniprot.org/citations/25078033 | http://purl.uniprot.org/core/author | "Castilho R.M."xsd:string |
| http://purl.uniprot.org/citations/25078033 | http://purl.uniprot.org/core/author | "Yocum A."xsd:string |
| http://purl.uniprot.org/citations/25078033 | http://purl.uniprot.org/core/author | "Inglehart R.C."xsd:string |
| http://purl.uniprot.org/citations/25078033 | http://purl.uniprot.org/core/author | "Metwally T."xsd:string |
| http://purl.uniprot.org/citations/25078033 | http://purl.uniprot.org/core/author | "Scanlon C.S."xsd:string |
| http://purl.uniprot.org/citations/25078033 | http://purl.uniprot.org/core/author | "Bellile E."xsd:string |
| http://purl.uniprot.org/citations/25078033 | http://purl.uniprot.org/core/author | "van Tubergen E."xsd:string |
| http://purl.uniprot.org/citations/25078033 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25078033 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/25078033 | http://purl.uniprot.org/core/pages | "4527"xsd:string |
| http://purl.uniprot.org/citations/25078033 | http://purl.uniprot.org/core/title | "TRIP13 promotes error-prone nonhomologous end joining and induces chemoresistance in head and neck cancer."xsd:string |
| http://purl.uniprot.org/citations/25078033 | http://purl.uniprot.org/core/volume | "5"xsd:string |