| http://purl.uniprot.org/citations/25091737 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25091737 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25091737 | http://www.w3.org/2000/01/rdf-schema#comment | "Treatment with individual anti-androgens is associated with the development of hot-spot mutations in the androgen receptor (AR). Here, we found that anti-androgens-mt-ARs have similar binary structure to the 5α-dihydrotestosterone-wt-AR. Phage display revealed that these ARs bound to similar peptides, including BUD31, containing an Fxx(F/H/L/W/Y)Y motif cluster with Tyr in the +5 position. Structural analyses of the AR-LBD-BUD31 complex revealed formation of an extra hydrogen bond between the Tyr+5 residue of the peptide and the AR. Functional studies showed that BUD31-related peptides suppressed AR transactivation, interrupted AR N-C interaction, and suppressed AR-mediated cell growth. Combination of peptide screening and X-ray structure analysis may serve as a new strategy for developing anti-ARs that simultaneously suppress both wt and mutated AR function."xsd:string |
| http://purl.uniprot.org/citations/25091737 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molonc.2014.06.009"xsd:string |
| http://purl.uniprot.org/citations/25091737 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molonc.2014.06.009"xsd:string |
| http://purl.uniprot.org/citations/25091737 | http://purl.uniprot.org/core/author | "Chen C.J."xsd:string |
| http://purl.uniprot.org/citations/25091737 | http://purl.uniprot.org/core/author | "Chen C.J."xsd:string |
| http://purl.uniprot.org/citations/25091737 | http://purl.uniprot.org/core/author | "Chen Y.L."xsd:string |
| http://purl.uniprot.org/citations/25091737 | http://purl.uniprot.org/core/author | "Chen Y.L."xsd:string |
| http://purl.uniprot.org/citations/25091737 | http://purl.uniprot.org/core/author | "Chang C."xsd:string |
| http://purl.uniprot.org/citations/25091737 | http://purl.uniprot.org/core/author | "Chang C."xsd:string |
| http://purl.uniprot.org/citations/25091737 | http://purl.uniprot.org/core/author | "Wu W.G."xsd:string |
| http://purl.uniprot.org/citations/25091737 | http://purl.uniprot.org/core/author | "Wu W.G."xsd:string |
| http://purl.uniprot.org/citations/25091737 | http://purl.uniprot.org/core/author | "Liu J.S."xsd:string |
| http://purl.uniprot.org/citations/25091737 | http://purl.uniprot.org/core/author | "Liu J.S."xsd:string |
| http://purl.uniprot.org/citations/25091737 | http://purl.uniprot.org/core/author | "Guan H.H."xsd:string |
| http://purl.uniprot.org/citations/25091737 | http://purl.uniprot.org/core/author | "Guan H.H."xsd:string |
| http://purl.uniprot.org/citations/25091737 | http://purl.uniprot.org/core/author | "Hsu C.L."xsd:string |
| http://purl.uniprot.org/citations/25091737 | http://purl.uniprot.org/core/author | "Hsu C.L."xsd:string |
| http://purl.uniprot.org/citations/25091737 | http://purl.uniprot.org/core/author | "Lin A.C."xsd:string |
| http://purl.uniprot.org/citations/25091737 | http://purl.uniprot.org/core/author | "Lin A.C."xsd:string |
| http://purl.uniprot.org/citations/25091737 | http://purl.uniprot.org/core/author | "Ma W.L."xsd:string |
| http://purl.uniprot.org/citations/25091737 | http://purl.uniprot.org/core/author | "Ma W.L."xsd:string |
| http://purl.uniprot.org/citations/25091737 | http://purl.uniprot.org/core/author | "Pang S.T."xsd:string |
| http://purl.uniprot.org/citations/25091737 | http://purl.uniprot.org/core/author | "Pang S.T."xsd:string |