| http://purl.uniprot.org/citations/25152461 | http://purl.uniprot.org/core/author | "Li L."xsd:string |
| http://purl.uniprot.org/citations/25152461 | http://purl.uniprot.org/core/name | "Brain Res"xsd:string |
| http://purl.uniprot.org/citations/25152461 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25152461 |
| http://purl.uniprot.org/citations/25152461 | http://www.w3.org/2000/01/rdf-schema#comment | "Amyloid precursor protein (APP) and β-site amyloid precursor protein cleaving enzyme (BACE-1) play important roles in the generation of Alzheimer׳s disease (AD), a progressive neurodegenerative disorder. In the present study, microRNA (miR) microarray was used to analyze the miR expression profiles in the hippocampi from APP/PS1 transgenic and wild type mice. The miRs with significant alteration and putative targets on APP or BACE-1 were retrieved (miR-135a, -200b and -429). The deregulations of these miRs were confirmed in mice and further verified in AD patient samples by qPCR. Primary mouse hippocampal neurons, SH-SY5Y and HEK293 cells were used to study the function of miRs on APP and BACE-1. We found that miR-135a, which was downregulated significantly in hippocampi from APP/PS1 transgenic mice compared with the wild type control, directly interacted with the 3'-UTR of BACE-1 and repressed its expression and activity. On the other hand, miR-200b and -429, which were downregulated significantly in hippocampi from APP/PS1 transgenic mice compared with the wild type control, targeted the 3'-UTR of APP and repressed its expression. Furthermore, Aβ42 could downregulate miR-200b expression which may generate a vicious cycle resulted in accumulating Aβ42. The levels of miR-135a and -200b in the serum of DAT group were significantly lower than that of control groups (P<0.05). The serum miR-200b level of MCI group was higher than that of DAT group (P<0.05) and lower than that of control group (P<0.05). We also found decreased miR-135a and -200b levels in the cerebrospinal fluid of DAT group compared with the control group (P<0.05). In conclusion, these findings showed that miR-135a, -200b and -429 may take part in the progress of AD; miR-200b was of great potential as noninvasive and easily detected blood-based biomarkers of MCI and DAT patients."xsd:string |
| http://purl.uniprot.org/citations/25152461 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.brainres.2014.04.026"xsd:string |
| http://purl.uniprot.org/citations/25152461 | http://purl.uniprot.org/core/pages | "55-64"xsd:string |
| http://purl.uniprot.org/citations/25152461 | http://purl.uniprot.org/core/volume | "1583"xsd:string |
| http://purl.uniprot.org/citations/25152461 | http://purl.uniprot.org/core/author | "Wang J.L."xsd:string |
| http://purl.uniprot.org/citations/25152461 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25152461 | http://purl.uniprot.org/core/author | "Liu C.G."xsd:string |
| http://purl.uniprot.org/citations/25152461 | http://purl.uniprot.org/core/author | "Zhang Y.Q."xsd:string |
| http://purl.uniprot.org/citations/25152461 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25152461 |
| http://purl.uniprot.org/citations/25152461 | http://purl.uniprot.org/core/author | "Wang P.C."xsd:string |
| http://purl.uniprot.org/citations/25152461 | http://purl.uniprot.org/core/title | "MicroRNA-135a and -200b, potential Biomarkers for Alzheimer׳s disease, regulate beta secretase and amyloid precursor protein."xsd:string |
| http://purl.uniprot.org/citations/25152461 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25152461 | http://purl.uniprot.org/core/author | "Xue L.X."xsd:string |