| http://purl.uniprot.org/citations/25193116 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25193116 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25193116 | http://www.w3.org/2000/01/rdf-schema#comment | "Coiled-coil domain containing 3 (CCDC3) is a newly identified secretory protein that is expressed in vascular endothelial cells (ECs) and adipose tissues. Here, we investigate the role of CCDC3 in tumor necrosis factor (TNF)-α-induced inflammatory response in ECs. Our results show that stable overexpression of CCDC3 decreases, while stable knockdown of the endogenous CCDC3 increases TNF-α-induced expression of vascular cell adhesion molecule-1 (VCAM-1) at the mRNA and protein level in ECs. The IκB kinase inhibitor Bay 11-7082 completely blocks TNF-α-induced expression of VCAM-1, confirming that TNF-α-induced expression of VCAM-1 in ECs is nuclear factor κB (NF-κB) dependent. Stable overexpression of CCDC3 decreases TNF-α-induced p65 and p50 nuclear translocation and NF-κB transcriptional activity, suggesting that CCDC3 inhibits TNF-α-induced NF-κB activation in ECs. Similar to CCDC3 overexpression, both CCDC3-containing conditioned medium (CM) and purified CCDC3 decrease TNF-α-induced expression of VCAM-1 in receiving ECs, suggesting a paracrine/autocrine function of CCDC3. Interestingly, CCDC3 in CM can enter the receiving ECs. Taken together, our work demonstrates that CCDC3 represses TNF-α/NF-κB-induced pro-inflammatory response in ECs, providing an insight into the functional role of CCDC3."xsd:string |
| http://purl.uniprot.org/citations/25193116 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cellsig.2014.08.025"xsd:string |
| http://purl.uniprot.org/citations/25193116 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cellsig.2014.08.025"xsd:string |
| http://purl.uniprot.org/citations/25193116 | http://purl.uniprot.org/core/author | "Chakrabarti S."xsd:string |
| http://purl.uniprot.org/citations/25193116 | http://purl.uniprot.org/core/author | "Chakrabarti S."xsd:string |
| http://purl.uniprot.org/citations/25193116 | http://purl.uniprot.org/core/author | "Fu Y."xsd:string |
| http://purl.uniprot.org/citations/25193116 | http://purl.uniprot.org/core/author | "Fu Y."xsd:string |
| http://purl.uniprot.org/citations/25193116 | http://purl.uniprot.org/core/author | "Xu Z."xsd:string |
| http://purl.uniprot.org/citations/25193116 | http://purl.uniprot.org/core/author | "Xu Z."xsd:string |
| http://purl.uniprot.org/citations/25193116 | http://purl.uniprot.org/core/author | "Azad A.K."xsd:string |
| http://purl.uniprot.org/citations/25193116 | http://purl.uniprot.org/core/author | "Azad A.K."xsd:string |
| http://purl.uniprot.org/citations/25193116 | http://purl.uniprot.org/core/author | "Davidge S.T."xsd:string |
| http://purl.uniprot.org/citations/25193116 | http://purl.uniprot.org/core/author | "Davidge S.T."xsd:string |
| http://purl.uniprot.org/citations/25193116 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25193116 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25193116 | http://purl.uniprot.org/core/name | "Cell. Signal."xsd:string |
| http://purl.uniprot.org/citations/25193116 | http://purl.uniprot.org/core/name | "Cell. Signal."xsd:string |
| http://purl.uniprot.org/citations/25193116 | http://purl.uniprot.org/core/pages | "2793-2800"xsd:string |
| http://purl.uniprot.org/citations/25193116 | http://purl.uniprot.org/core/pages | "2793-2800"xsd:string |
| http://purl.uniprot.org/citations/25193116 | http://purl.uniprot.org/core/title | "Coiled-coil domain containing 3 (CCDC3) represses tumor necrosis factor-alpha/nuclear factor kappaB-induced endothelial inflammation."xsd:string |
| http://purl.uniprot.org/citations/25193116 | http://purl.uniprot.org/core/title | "Coiled-coil domain containing 3 (CCDC3) represses tumor necrosis factor-alpha/nuclear factor kappaB-induced endothelial inflammation."xsd:string |
| http://purl.uniprot.org/citations/25193116 | http://purl.uniprot.org/core/volume | "26"xsd:string |
| http://purl.uniprot.org/citations/25193116 | http://purl.uniprot.org/core/volume | "26"xsd:string |