| http://purl.uniprot.org/citations/25303524 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25303524 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25303524 | http://www.w3.org/2000/01/rdf-schema#comment | "Discrimination between pathogenic and beneficial microbes is essential for host organism immunity and homeostasis. Here, we show that chemosensory detection of two secondary metabolites produced by Pseudomonas aeruginosa modulates a neuroendocrine signaling pathway that promotes avoidance behavior in the simple animal host Caenorhabditis elegans. Secondary metabolites phenazine-1-carboxamide and pyochelin activate a G-protein-signaling pathway in the ASJ chemosensory neuron pair that induces expression of the neuromodulator DAF-7/TGF-β. DAF-7, in turn, activates a canonical TGF-β signaling pathway in adjacent interneurons to modulate aerotaxis behavior and promote avoidance of pathogenic P. aeruginosa. Our data provide a chemical, genetic, and neuronal basis for how the behavior and physiology of a simple animal host can be modified by the microbial environment and suggest that secondary metabolites produced by microbes may provide environmental cues that contribute to pathogen recognition and host survival."xsd:string |
| http://purl.uniprot.org/citations/25303524 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2014.09.011"xsd:string |
| http://purl.uniprot.org/citations/25303524 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2014.09.011"xsd:string |
| http://purl.uniprot.org/citations/25303524 | http://purl.uniprot.org/core/author | "Kim D.H."xsd:string |
| http://purl.uniprot.org/citations/25303524 | http://purl.uniprot.org/core/author | "Kim D.H."xsd:string |
| http://purl.uniprot.org/citations/25303524 | http://purl.uniprot.org/core/author | "Schroeder F.C."xsd:string |
| http://purl.uniprot.org/citations/25303524 | http://purl.uniprot.org/core/author | "Schroeder F.C."xsd:string |
| http://purl.uniprot.org/citations/25303524 | http://purl.uniprot.org/core/author | "Mahanti P."xsd:string |
| http://purl.uniprot.org/citations/25303524 | http://purl.uniprot.org/core/author | "Mahanti P."xsd:string |
| http://purl.uniprot.org/citations/25303524 | http://purl.uniprot.org/core/author | "Panda O."xsd:string |
| http://purl.uniprot.org/citations/25303524 | http://purl.uniprot.org/core/author | "Panda O."xsd:string |
| http://purl.uniprot.org/citations/25303524 | http://purl.uniprot.org/core/author | "Meisel J.D."xsd:string |
| http://purl.uniprot.org/citations/25303524 | http://purl.uniprot.org/core/author | "Meisel J.D."xsd:string |
| http://purl.uniprot.org/citations/25303524 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25303524 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25303524 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/25303524 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/25303524 | http://purl.uniprot.org/core/pages | "267-280"xsd:string |
| http://purl.uniprot.org/citations/25303524 | http://purl.uniprot.org/core/pages | "267-280"xsd:string |
| http://purl.uniprot.org/citations/25303524 | http://purl.uniprot.org/core/title | "Chemosensation of bacterial secondary metabolites modulates neuroendocrine signaling and behavior of C. elegans."xsd:string |
| http://purl.uniprot.org/citations/25303524 | http://purl.uniprot.org/core/title | "Chemosensation of bacterial secondary metabolites modulates neuroendocrine signaling and behavior of C. elegans."xsd:string |
| http://purl.uniprot.org/citations/25303524 | http://purl.uniprot.org/core/volume | "159"xsd:string |
| http://purl.uniprot.org/citations/25303524 | http://purl.uniprot.org/core/volume | "159"xsd:string |