| http://purl.uniprot.org/citations/25380047 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25380047 | http://www.w3.org/2000/01/rdf-schema#comment | "Septins (SEPTs) form a family of GTP-binding proteins implicated in cytoskeleton and membrane organization, cell division and host/pathogen interactions. The precise function of many family members remains elusive. We show that SEPT6 and SEPT7 complexes bound to F-actin regulate protein sorting during multivesicular body (MVB) biogenesis. These complexes bind AP-3, an adapter complex sorting cargos destined to remain in outer membranes of maturing endosomes, modulate AP-3 membrane interactions and the motility of AP-3-positive endosomes. These SEPT-AP interactions also influence the membrane interaction of ESCRT (endosomal-sorting complex required for transport)-I, which selects ubiquitinated cargos for degradation inside MVBs. Whereas our findings demonstrate that SEPT6 and SEPT7 function in the spatial, temporal organization of AP-3- and ESCRT-coated membrane domains, they uncover an unsuspected coordination of these sorting machineries during MVB biogenesis. This requires the E3 ubiquitin ligase LRSAM1, an AP-3 interactor regulating ESCRT-I sorting activity and whose mutations are linked with Charcot-Marie-Tooth neuropathies."xsd:string |
| http://purl.uniprot.org/citations/25380047 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0109372"xsd:string |
| http://purl.uniprot.org/citations/25380047 | http://purl.uniprot.org/core/author | "Raposo G."xsd:string |
| http://purl.uniprot.org/citations/25380047 | http://purl.uniprot.org/core/author | "Stange C."xsd:string |
| http://purl.uniprot.org/citations/25380047 | http://purl.uniprot.org/core/author | "Salamero J."xsd:string |
| http://purl.uniprot.org/citations/25380047 | http://purl.uniprot.org/core/author | "Hoflack B."xsd:string |
| http://purl.uniprot.org/citations/25380047 | http://purl.uniprot.org/core/author | "Wassmer T."xsd:string |
| http://purl.uniprot.org/citations/25380047 | http://purl.uniprot.org/core/author | "Traikov S."xsd:string |
| http://purl.uniprot.org/citations/25380047 | http://purl.uniprot.org/core/author | "Paul-Gilloteaux P."xsd:string |
| http://purl.uniprot.org/citations/25380047 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25380047 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/25380047 | http://purl.uniprot.org/core/pages | "e109372"xsd:string |
| http://purl.uniprot.org/citations/25380047 | http://purl.uniprot.org/core/title | "Septin6 and Septin7 GTP binding proteins regulate AP-3- and ESCRT-dependent multivesicular body biogenesis."xsd:string |
| http://purl.uniprot.org/citations/25380047 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/25380047 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25380047 |
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