| http://purl.uniprot.org/citations/25425738 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25425738 | http://www.w3.org/2000/01/rdf-schema#comment | "Lipid rafts, a liquid-ordered plasma membrane microdomain, are related to cell-surface receptor function. PSGL-1, a major surface receptor protein for leukocyte, also acts as a signaling receptor in leukocyte rolling. To investigate the role of lipid raft in PSGL-1 signaling in human neutrophils, we quantitatively analyzed lipid raft proteome of human promyelocytic leukemia cell line HL-60 cells and identified a lipid raft-associated protein β-adducin. PSGL-1 ligation induced dissociation of the raft-associated protein β-adducin from lipid rafts and actin, as well as phosphorylation of β-adducin, indicating a transient uncoupling of lipid rafts from the actin cytoskeleton. Knockdown of β-adducin greatly attenuated HL-60 cells rolling on P-selectin. We also showed that Src kinase is crucial for PSGL-1 ligation-induced β-adducin phosphorylation and relocation. Taken together, these results show that β-adducin is a pivotal lipid raft-associated protein in PSGL-1-mediated neutrophil rolling on P-selectin."xsd:string |
| http://purl.uniprot.org/citations/25425738 | http://purl.org/dc/terms/identifier | "doi:10.1189/jlb.2a0114-016r"xsd:string |
| http://purl.uniprot.org/citations/25425738 | http://purl.uniprot.org/core/author | "Jiang Y."xsd:string |
| http://purl.uniprot.org/citations/25425738 | http://purl.uniprot.org/core/author | "Liu W."xsd:string |
| http://purl.uniprot.org/citations/25425738 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/25425738 | http://purl.uniprot.org/core/author | "Yang C."xsd:string |
| http://purl.uniprot.org/citations/25425738 | http://purl.uniprot.org/core/author | "Zeng X."xsd:string |
| http://purl.uniprot.org/citations/25425738 | http://purl.uniprot.org/core/author | "Xu T."xsd:string |
| http://purl.uniprot.org/citations/25425738 | http://purl.uniprot.org/core/author | "Ba X."xsd:string |
| http://purl.uniprot.org/citations/25425738 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25425738 | http://purl.uniprot.org/core/name | "J Leukoc Biol"xsd:string |
| http://purl.uniprot.org/citations/25425738 | http://purl.uniprot.org/core/pages | "297-306"xsd:string |
| http://purl.uniprot.org/citations/25425738 | http://purl.uniprot.org/core/title | "Lipid raft-associated beta-adducin is required for PSGL-1-mediated neutrophil rolling on P-selectin."xsd:string |
| http://purl.uniprot.org/citations/25425738 | http://purl.uniprot.org/core/volume | "97"xsd:string |
| http://purl.uniprot.org/citations/25425738 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25425738 |
| http://purl.uniprot.org/citations/25425738 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25425738 |
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