| http://purl.uniprot.org/citations/25512524 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25512524 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25512524 | http://www.w3.org/2000/01/rdf-schema#comment | "Pumilio/feminization of XX and XO animals (fem)-3 mRNA-binding factor (PUF) proteins bind sequence specifically to mRNA targets using a single-stranded RNA-binding domain comprising eight Pumilio (PUM) repeats. PUM repeats have now been identified in proteins that function in pre-rRNA processing, including human Puf-A and yeast Puf6. This is a role not previously ascribed to PUF proteins. Here we present crystal structures of human Puf-A that reveal a class of nucleic acid-binding proteins with 11 PUM repeats arranged in an "L"-like shape. In contrast to classical PUF proteins, Puf-A forms sequence-independent interactions with DNA or RNA, mediated by conserved basic residues. We demonstrate that equivalent basic residues in yeast Puf6 are important for RNA binding, pre-rRNA processing, and mRNA localization. Thus, PUM repeats can be assembled into alternative folds that bind to structured nucleic acids in addition to forming canonical eight-repeat crescent-shaped RNA-binding domains found in classical PUF proteins."xsd:string |
| http://purl.uniprot.org/citations/25512524 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1407634112"xsd:string |
| http://purl.uniprot.org/citations/25512524 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1407634112"xsd:string |
| http://purl.uniprot.org/citations/25512524 | http://purl.uniprot.org/core/author | "Qiu C."xsd:string |
| http://purl.uniprot.org/citations/25512524 | http://purl.uniprot.org/core/author | "Qiu C."xsd:string |
| http://purl.uniprot.org/citations/25512524 | http://purl.uniprot.org/core/author | "Baserga S.J."xsd:string |
| http://purl.uniprot.org/citations/25512524 | http://purl.uniprot.org/core/author | "Baserga S.J."xsd:string |
| http://purl.uniprot.org/citations/25512524 | http://purl.uniprot.org/core/author | "McCann K.L."xsd:string |
| http://purl.uniprot.org/citations/25512524 | http://purl.uniprot.org/core/author | "McCann K.L."xsd:string |
| http://purl.uniprot.org/citations/25512524 | http://purl.uniprot.org/core/author | "Wine R.N."xsd:string |
| http://purl.uniprot.org/citations/25512524 | http://purl.uniprot.org/core/author | "Wine R.N."xsd:string |
| http://purl.uniprot.org/citations/25512524 | http://purl.uniprot.org/core/author | "Hall T.M."xsd:string |
| http://purl.uniprot.org/citations/25512524 | http://purl.uniprot.org/core/author | "Hall T.M."xsd:string |
| http://purl.uniprot.org/citations/25512524 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25512524 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25512524 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/25512524 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/25512524 | http://purl.uniprot.org/core/pages | "18554-18559"xsd:string |
| http://purl.uniprot.org/citations/25512524 | http://purl.uniprot.org/core/pages | "18554-18559"xsd:string |
| http://purl.uniprot.org/citations/25512524 | http://purl.uniprot.org/core/title | "A divergent Pumilio repeat protein family for pre-rRNA processing and mRNA localization."xsd:string |
| http://purl.uniprot.org/citations/25512524 | http://purl.uniprot.org/core/title | "A divergent Pumilio repeat protein family for pre-rRNA processing and mRNA localization."xsd:string |
| http://purl.uniprot.org/citations/25512524 | http://purl.uniprot.org/core/volume | "111"xsd:string |
| http://purl.uniprot.org/citations/25512524 | http://purl.uniprot.org/core/volume | "111"xsd:string |