| http://purl.uniprot.org/citations/25525117 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25525117 | http://www.w3.org/2000/01/rdf-schema#comment | "The impairment of cytotoxic activity of lymphocytes disturbs immune surveillance and leads to the development of hemophagocytic lymphohistiocytic syndrome (HLH). Although cytotoxic T lymphocyte (CTL) control of HLH development is well documented, the role for natural killer (NK)-cell effector functions in the pathogenesis of this immune disorder remains unclear. In this study, we specifically targeted a defect in cytotoxicity to either CTL or NK cells in mice so as to dissect the contribution of these lymphocyte subsets to HLH-like disease severity after lymphocytic choriomeningitis virus (LCMV) infection. We found that NK-cell cytotoxicity was sufficient to protect mice from the fatal outcome that characterizes HLH-like disease and was also sufficient to reduce HLH-like manifestations. Mechanistically, NK-cell cytotoxicity reduced tissue infiltration by inflammatory macrophages and downmodulated LCMV-specific T-cell responses by limiting hyperactivation of CTL. Interestingly, the critical protective effect of NK cells on HLH was independent of interferon-γ secretion and changes in viral load. Therefore our findings identify a crucial role of NK-cell cytotoxicity in limiting HLH-like immunopathology, highlighting the important role of NK cytotoxic activity in immune homeostasis."xsd:string |
| http://purl.uniprot.org/citations/25525117 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2014-09-602946"xsd:string |
| http://purl.uniprot.org/citations/25525117 | http://purl.uniprot.org/core/author | "Fischer A."xsd:string |
| http://purl.uniprot.org/citations/25525117 | http://purl.uniprot.org/core/author | "de Saint Basile G."xsd:string |
| http://purl.uniprot.org/citations/25525117 | http://purl.uniprot.org/core/author | "Di Santo J.P."xsd:string |
| http://purl.uniprot.org/citations/25525117 | http://purl.uniprot.org/core/author | "Sepulveda F.E."xsd:string |
| http://purl.uniprot.org/citations/25525117 | http://purl.uniprot.org/core/author | "Menasche G."xsd:string |
| http://purl.uniprot.org/citations/25525117 | http://purl.uniprot.org/core/author | "Garrigue A."xsd:string |
| http://purl.uniprot.org/citations/25525117 | http://purl.uniprot.org/core/author | "Kurowska M."xsd:string |
| http://purl.uniprot.org/citations/25525117 | http://purl.uniprot.org/core/author | "Maschalidi S."xsd:string |
| http://purl.uniprot.org/citations/25525117 | http://purl.uniprot.org/core/author | "Vosshenrich C.A."xsd:string |
| http://purl.uniprot.org/citations/25525117 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25525117 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/25525117 | http://purl.uniprot.org/core/pages | "1427-1434"xsd:string |
| http://purl.uniprot.org/citations/25525117 | http://purl.uniprot.org/core/title | "A novel immunoregulatory role for NK-cell cytotoxicity in protection from HLH-like immunopathology in mice."xsd:string |
| http://purl.uniprot.org/citations/25525117 | http://purl.uniprot.org/core/volume | "125"xsd:string |
| http://purl.uniprot.org/citations/25525117 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25525117 |
| http://purl.uniprot.org/citations/25525117 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25525117 |
| http://purl.uniprot.org/uniprot/#_A0A1W2P6E3-mappedCitation-25525117 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25525117 |
| http://purl.uniprot.org/uniprot/#_A0A1W2P6Y3-mappedCitation-25525117 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25525117 |
| http://purl.uniprot.org/uniprot/#_A2RSY7-mappedCitation-25525117 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25525117 |
| http://purl.uniprot.org/uniprot/#_P10820-mappedCitation-25525117 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25525117 |
| http://purl.uniprot.org/uniprot/#_Q3TAS3-mappedCitation-25525117 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25525117 |
| http://purl.uniprot.org/uniprot/#_Q3U5V8-mappedCitation-25525117 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25525117 |