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http://purl.uniprot.org/citations/25657994http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/25657994http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/25657994http://www.w3.org/2000/01/rdf-schema#comment"BRCA1-associated ATM activator-1 (BRAT1) was identified by our group as a DNA damage response (DDR) protein, which can bind with many DDR proteins and regulates their functions after DNA damage. However, previous study has also implicated BRAT1 as a regulator of cell growth and apoptosis. In this study, targeted gene deletion showed that BRAT1 is critical in stability and serum-induced expression of mTOR and downstream protein. Conditional deletion of BRAT1 of mouse embryonic fibroblasts suppressed serum-induced cell cycling progress. Our results suggest that BRAT1 is essential factor for PIKK signaling cascades."xsd:string
http://purl.uniprot.org/citations/25657994http://purl.uniprot.org/core/author"Ouchi T."xsd:string
http://purl.uniprot.org/citations/25657994http://purl.uniprot.org/core/author"Ouchi T."xsd:string
http://purl.uniprot.org/citations/25657994http://purl.uniprot.org/core/author"So E.Y."xsd:string
http://purl.uniprot.org/citations/25657994http://purl.uniprot.org/core/author"So E.Y."xsd:string
http://purl.uniprot.org/citations/25657994http://purl.uniprot.org/core/date"2013"xsd:gYear
http://purl.uniprot.org/citations/25657994http://purl.uniprot.org/core/date"2013"xsd:gYear
http://purl.uniprot.org/citations/25657994http://purl.uniprot.org/core/name"J. Cancer Biol. Res."xsd:string
http://purl.uniprot.org/citations/25657994http://purl.uniprot.org/core/name"J. Cancer Biol. Res."xsd:string
http://purl.uniprot.org/citations/25657994http://purl.uniprot.org/core/title"The potential role of BRCA1-associated ATM activator-1 (BRAT1) in regulation of mTOR."xsd:string
http://purl.uniprot.org/citations/25657994http://purl.uniprot.org/core/title"The potential role of BRCA1-associated ATM activator-1 (BRAT1) in regulation of mTOR."xsd:string
http://purl.uniprot.org/citations/25657994http://purl.uniprot.org/core/volume"1"xsd:string
http://purl.uniprot.org/citations/25657994http://purl.uniprot.org/core/volume"1"xsd:string
http://purl.uniprot.org/citations/25657994http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/25657994
http://purl.uniprot.org/citations/25657994http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/25657994
http://purl.uniprot.org/citations/25657994http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/25657994
http://purl.uniprot.org/citations/25657994http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/25657994
http://purl.uniprot.org/uniprot/P42345http://purl.uniprot.org/core/citationhttp://purl.uniprot.org/citations/25657994
http://purl.uniprot.org/uniprot/Q8N122http://purl.uniprot.org/core/citationhttp://purl.uniprot.org/citations/25657994
http://purl.uniprot.org/uniprot/Q8C3R1http://purl.uniprot.org/core/citationhttp://purl.uniprot.org/citations/25657994
http://purl.uniprot.org/uniprot/Q6PJG6http://purl.uniprot.org/core/citationhttp://purl.uniprot.org/citations/25657994
http://purl.uniprot.org/uniprot/Q8C3R1#attribution-4DDA040657801AF125513D9765980AAEhttp://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/25657994
http://purl.uniprot.org/uniprot/Q6PJG6#attribution-DAF941B7E67D1FCD6FD5AA44B7E886E6http://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/25657994