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http://purl.uniprot.org/citations/25662211http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/25662211http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/25662211http://www.w3.org/2000/01/rdf-schema#comment"Cancer testis antigens (CTAs) represented a poorly characterized group of proteins whose expression is normally restricted to testis but are frequently up-regulated in cancer cells. Here we show that one CTA, Luzp4, is an mRNA export adaptor. It associates with the TREX mRNA export complex subunit Uap56 and harbours a Uap56 binding motif, conserved in other mRNA export adaptors. Luzp4 binds the principal mRNA export receptor Nxf1, enhances its RNA binding activity and complements Alyref knockdown in vivo. Whilst Luzp4 is up-regulated in a range of tumours, it appears preferentially expressed in melanoma cells where it is required for growth."xsd:string
http://purl.uniprot.org/citations/25662211http://purl.org/dc/terms/identifier"doi:10.1093/nar/gkv070"xsd:string
http://purl.uniprot.org/citations/25662211http://purl.org/dc/terms/identifier"doi:10.1093/nar/gkv070"xsd:string
http://purl.uniprot.org/citations/25662211http://purl.uniprot.org/core/author"Wilson S.A."xsd:string
http://purl.uniprot.org/citations/25662211http://purl.uniprot.org/core/author"Wilson S.A."xsd:string
http://purl.uniprot.org/citations/25662211http://purl.uniprot.org/core/author"Dickman M.J."xsd:string
http://purl.uniprot.org/citations/25662211http://purl.uniprot.org/core/author"Dickman M.J."xsd:string
http://purl.uniprot.org/citations/25662211http://purl.uniprot.org/core/author"Viphakone N."xsd:string
http://purl.uniprot.org/citations/25662211http://purl.uniprot.org/core/author"Viphakone N."xsd:string
http://purl.uniprot.org/citations/25662211http://purl.uniprot.org/core/author"Heath P.R."xsd:string
http://purl.uniprot.org/citations/25662211http://purl.uniprot.org/core/author"Heath P.R."xsd:string
http://purl.uniprot.org/citations/25662211http://purl.uniprot.org/core/author"Catto J.W."xsd:string
http://purl.uniprot.org/citations/25662211http://purl.uniprot.org/core/author"Catto J.W."xsd:string
http://purl.uniprot.org/citations/25662211http://purl.uniprot.org/core/author"Cumberbatch M.G."xsd:string
http://purl.uniprot.org/citations/25662211http://purl.uniprot.org/core/author"Cumberbatch M.G."xsd:string
http://purl.uniprot.org/citations/25662211http://purl.uniprot.org/core/author"Livingstone M.J."xsd:string
http://purl.uniprot.org/citations/25662211http://purl.uniprot.org/core/author"Livingstone M.J."xsd:string
http://purl.uniprot.org/citations/25662211http://purl.uniprot.org/core/date"2015"xsd:gYear
http://purl.uniprot.org/citations/25662211http://purl.uniprot.org/core/date"2015"xsd:gYear
http://purl.uniprot.org/citations/25662211http://purl.uniprot.org/core/name"Nucleic Acids Res."xsd:string
http://purl.uniprot.org/citations/25662211http://purl.uniprot.org/core/name"Nucleic Acids Res."xsd:string
http://purl.uniprot.org/citations/25662211http://purl.uniprot.org/core/pages"2353-2366"xsd:string
http://purl.uniprot.org/citations/25662211http://purl.uniprot.org/core/pages"2353-2366"xsd:string